Esmolol detailed information
Clinical data | |
---|---|
Pregnancy category | |
Routes of administration | iv |
ATC code | |
Pharmacokinetic data | |
Bioavailability | - |
Protein binding | 60% |
Metabolism | Erythrocytic |
Elimination half-life | 9 minutes |
Excretion | Renal |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C16H25NO4> |
Molar mass | 295.374 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Esmolol (trade name Brevibloc) is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic parasympathomimetic or membrane stabilising activity at therapeutic dosages.
Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart, lungs and other organs of the body. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.
Dosing
Esmolol is given by slow intravenous injection. It is commonly used in patients during surgery to prevent or treat tachycardia, and is also used in treatment of acute supraventricular tachycardia.
Metabolism
Esmolol is rapidly hydrolysed by the esterases in the cytosol of red blood cells. Plasma cholinesterases and red cell membrane acetylcholinesterase do not have any action. This metabolism results in the formation of a free acid and methanol. The amount of methanol produced is similar to endogenous methanol production. Its elimination half-life is about 9 minutes.
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles with erroneous molar mass calculations
- Chemical articles with unknown parameter in Infobox drug
- Infobox drug articles without a structure image
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Beta blockers
- Drugs