Olmesartan detailed information

Olmesartan detailed information

Clinical data
Pregnancy category	C (D if used in second or third trimester)
Routes of administration	Oral
ATC code	C09CA08 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Rapid and complete absorption
Metabolism	Hepatic (cannot be removed by hemodialysis)
Elimination half-life	13 hours
Excretion	Primarily fecal, 35%-50% in urine
Identifiers
IUPAC name (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[ [4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
CAS Number	144689-63-4
PubChem CID	130881
DrugBank	APRD00223
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C29H30N6O6
Molar mass	558.585 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Olmesartan (Benicar®,Olmetec®) belongs to the class of medicines called angiotensin II receptor antagonists to treat high blood pressure. It is marketed worldwide by Daiichi Sankyo, Ltd. and in the United States by Daiichi Sankyo, Inc. and Forest Laboratories. Olmesartan works by blocking the binding of angiotension II to the AT₁ receptors in vascular muscle; it is therefore independent of angiotension II synthesis pathways, unlike ACE inhibitors. By blocking binding rather than synthesis of angiotension II, olmesartan inhibits the negative regulatory feedback on renin secretion. As a result of this blockage, olmesartan restricts vasoconstriction and the secretion of aldosterone. This lowers blood pressure by producing vasodilation, and decreasing peripheral resistance.

Administration

Olmesartan is available in 5, 20, and 40 mg tablets. A normal dose for an adult (including the elderly and mild renal or hepatic impairment) is 20 mg/day in one dosage. This may be increased after two weeks to 40 mg/day if further blood pressure reduction is needed.

Side effects

Side effects include:

• Dizziness
• Headache
• Diarrhea
• Upper respiratory tract infection

References

Hodgson, Barbara B., and Kizior, Robert J. Saunders Nursing Drug Handbook 2006. St. Louis, MO: Elsevier, Saunders, 2006.

External links

• Forest Laboratories Benicar page

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