N-Methyl-3-piperidyl benzilate

N-Methyl-3-piperidyl benzilate

File:Methylpiperidinylbenzilate.svg
Legal status
Legal status	US: Schedule I
Identifiers
IUPAC name (1-methylpiperidin-3-yl) 2-hydroxy-2,2-di(phenyl)acetate
CAS Number	3321-80-0
PubChem CID	62495
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C20H23NO3
Molar mass	325.40 g/mol

N-methyl-3-piperidyl benzilate (JB-336) is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate.

N-methyl-3-piperidyl benzilate is less potent and shorter acting than 3-quinuclidyl benzilate, but like 3-QNB its effects on the central nervous system predominate over peripheral effects. It produces deliriant and hallucinogenic effects similar to those of plants such as datura and may be abused recreationally at low doses, however unpleasant side effects such as dysphoria, nausea and vomiting, dizziness and extreme dry mouth tend to make abuse of these kind of drugs uncommon. Both the N-methyl and N-ethyl analogues of 3-piperidyl benzilate are however Schedule I controlled drugs.

Radiolabelled versions of this drug are used in scientific research to map the distribution of muscarinic acetylcholine receptors in the brain.

See also

• N-ethyl-3-piperidyl benzilate
• 3-Quinuclidinyl benzilate

References

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