Zollinger-Ellison syndrome
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| Zollinger-Ellison syndrome | |
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| Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger-Ellison syndrome | |
| ICD-10 | E16.4 |
| ICD-9 | 251.5 |
| MedlinePlus | 000325 |
| eMedicine | med/2437 ped/2472 |
| MeSH | D015043 |
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Zollinger-Ellison syndrome Microchapters |
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Differentiating Zollinger-Ellison syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Zollinger-Ellison syndrome On the Web |
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American Roentgen Ray Society Images of Zollinger-Ellison syndrome |
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Risk calculators and risk factors for Zollinger-Ellison syndrome |
Overview
Historical Perspective
Pathophysiology
Epidemiology & Demographics
Risk Factors
Screening
Causes
Differentiating Zollinger-Ellison syndrome
Complications & Prognosis
Diagnosis
History and Symptoms | Physical Examination | Staging | Laboratory tests | Electrocardiogram | X Rays | CT | MRI Echocardiography or Ultrasound | Other images | Alternative diagnostics
Treatment
Medical therapy | Surgical options | Primary prevention | Secondary prevention | Financial costs | Future therapies
Diagnosis
The diagnosis of Zollinger-Ellison syndrome is made by several laboratory tests and imaging studies.
Laboratory tests:
- secretin stimulation test, which measures gastrin levels in response to secretin
- fasting gastrin levels
- antral acidity
Therapy
Proton pump inhibitors (such as omeprazole and lansoprazole) and histamine H2-receptor antagonists (such as famotidine and ranitidine) are used to slow down acid secretion. If possible the tumours should be surgically removed, or treated with chemotherapy.
Octreotide can be used to slow down acid secretion.
History
The disease entity was first described in 1955 by its namesakes: Zollinger RM, Ellison EH. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 1955;142:709-23. PMID 13259432.
External links
de:Zollinger-Ellison-Syndrom sv:Zollinger-Ellisons syndrom th:โรคเนื้องอกที่เกิดจากการหลั่งกรดผิดปกติ