Non-Hodgkin lymphoma
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| Non-Hodgkin's Lymphoma | |
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| Malignant lymphoma, high grade B cell, not otherwise specified (Courtesy of Ed Uthman, MD) | |
| ICD-10 | C82-C85 |
| ICD-9 | 200, 202 |
| ICD-O: | 9591/3 |
| OMIM | 605027 |
| DiseasesDB | 9065 |
| MedlinePlus | 000581 |
| MeSH | D008228 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Staging
If non-Hodgkin's lymphoma is diagnosed, the doctor needs to learn the stage, or extent, of the disease. Staging is a careful attempt to find out whether the cancer has spread and, if so, what parts of the body are affected. Treatment decisions depend on these findings.[1]
The doctor considers the following to determine the stage of non-Hodgkin's lymphoma:
- The number and location of affected lymph nodes;
- Whether the affected lymph nodes are above, below, or on both sides of the diaphragm (the thin muscle under the lungs and heart that separates the chest from the abdomen);
- Whether the disease has spread to the bone marrow, spleen, or to organs outside the lymphatic system, such as the liver;
and the testes.
- Whether B symptoms (systemic symptoms) such as fever, chills, night sweats, or weight loss are present.
In staging, the doctor may use some of the same tests used for the diagnosis of non-Hodgkin's lymphoma. Other staging procedures may include additional biopsies of lymph nodes, the liver, bone marrow, or other tissue. A bone marrow biopsy involves removing a sample of bone marrow through a needle inserted into the hip or another large bone. A pathologist examines the sample under a microscope to check for cancer cells.
Stages of NHL
The various stages of NHL (the Ann Arbor staging classification, developed for Hodgkin's lymphoma) are based on how far the cancer has spread throughout and beyond the lymphatic system, and whether constitutional symptoms (fever, night sweats, or weight loss) are present.
- Stage I
- "Stage I" indicates that the cancer is located in a single region, usually one lymph node and the surrounding area. Stage I often will not have outward symptoms.
- Stage II
- "Stage II" indicates that the cancer is located in two separate regions, an affected lymph node or organ within the lymphatic system and a second affected area, and that both affected areas are confined to one side of the diaphragm - that is, both are above the diaphragm, or both are below the diaphragm.
- Stage III
- "Stage III" indicates that the cancer has spread to both sides of the diaphragm, including one organ or area near the lymph nodes or the spleen.
- Stage IV
- "Stage IV" indicates that the cancer has spread beyond the lymphatic system and involves one or more major organs, possibly including the bone marrow or skin.
The absence of constitutional symptoms is denoted by adding an "A" to the stage; the presence is denoted by adding a "B" to the stage (hence the name B symptoms).
Staging in non-Hodgkin's lymphomas is far less significant in determining therapy than it is in Hodgkin's lymphoma
References
- ↑ "Staging NHL". Cancer Research UK 2002. Retrieved April 25. Unknown parameter
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External links
- "What You Need to Know About Non-Hodgkin's Lymphoma". NIH Publication No. 99-1567. Retrieved January 22. Unknown parameter
|accessyear=ignored (|access-date=suggested) (help); Check date values in:|accessdate=(help) - Lymphoma Research Foundation
- Mantle Cell Lymphoma Consortium
- The Leukemia & Lymphoma Society
- Understanding Non Hodgkin's Lymphoma from Lymphoma Support Ireland
- Lymphoma Information Network
- Non-Hodgkin's Lymphoma Clinical Research Study (commercial, sponsored by Genentech)
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