Cardiac amyloidosis cardiac biopsy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Cafer Zorkun, M.D., Ph.D. [2]

Cardiac biopsy

A cardiac biopsy that reveals amyloid confirms the diagnosis. Biopsy of other tissues may also confirm the diagnosis. Amyloidosis is frequently confirmed by biopsy of abdominal fat, kidney, or bone marrow.

Cardiac biopsy with Congo red staining & Immunostaining

• Congo red staining is used to establish the diagnosis of amyloidosis.

• Immunostaining of the biopsy specimen is required to identify the deposited protein and to differentiate between ATTR and AL types of cardiac amyloidosis.

References

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