Cardiac amyloidosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Cafer Zorkun, M.D., Ph.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]
Overview
Amyloidosis is a multi-system disease involving many organs simultaneously. Approximately more than 50% of the patients with amyloidosis present with right heart failure symptoms. The most common symptoms observed in patients with cardiac amyloidosis include fatigue, weight loss, and periorbital purpura.[1]
Symptoms
- Cardiac amyloid deposition can cause symptoms suggestive of:
- congestive heart failure such as fatigue, dyspnea, orthopnea[1], peripheral edema, ascites and/or
- arrhythmias such as palpitations
- Postural hypotension may be observed in patients with subendothelial amyloid deposition.[2]
References
- ↑ 1.0 1.1 Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help)