Cardiac amyloidosis cardiac biopsy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]

Overview

A cardiac biopsy that reveals amyloid confirms the diagnosis. Biopsy of other tissues may also confirm the diagnosis. Amyloidosis is frequently confirmed by biopsy of abdominal fat, rectal submucosa, kidney, or bone marrow.

Cardiac Biopsy

• Congo red staining is used to establish the diagnosis of amyloidosis.

• Immunostaining of the biopsy specimen is required to identify the deposited protein and to differentiate between ATTR and AL types of cardiac amyloidosis.

References

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