Tetralogy of fallot causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2], Keri Shafer, M.D. [3]; Atif Mohammad, M.D.; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]
Overview
Both environmental and genetic factors appear to be involved in the development of Tetralogy of Fallot.
Causes
Embryology studies show that it is a result of anterior malalignment of the conal septum, resulting in the clinical combination of a VSD, pulmonary stenosis, and an overriding aorta. Right ventricular hypertrophy results from this combination, which causes resistance to blood flow from the right ventricle.
The cause of most congenital heart defects is unknown. Many factors seem to be involved.
Factors that increase the risk for this condition during pregnancy include:
- Alcoholism in the mother
- Diabetes
- Mother who is over 40 years old
- Poor nutrition during pregnancy
- Rubella or other viral illnesses during pregnancy
- There is a high incidence of chromosomal disorders in children with tetralogy of Fallot, such as Down syndrome and diGeorge syndrome (chromosome 22 deletions) (a condition that causes heart defects, low calcium levels, and immune deficiency).
See also
References
External links
- Information by University of Michigan Health System
- Diagram of the condition
- Information for adults with ToF from the Adult Congenital Heart Association
de:Fallot-Tetralogie it:Tetralogia di Fallot nl:Tetralogie van Fallot nn:Fallots tetrade uk:Тетрада Фалло