Leg pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Common Causes

• Arterial thromboembolism
• Arthritis
• Autoimmune vascular disorders such as vasculitis
• Baker's cyst
• Cholesterol embolism
• Chronic venous insufficiency
• Connective tissue disease
• Coxsackie B
• Deep Vein Thrombosis (DVT)
• Drugs, toxins
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Leptospirosis
• Ligament damage
• Lumbar canal stenosis or spinal stenosis
• Muscle or tendon strain
• Night cramps
• Obliterating endarteritis
• Peripheral neuropathy
• Peripheral vascular disease
• Plexopathy
• Primary varicosis
• Radiculopathy
• Restless Leg Syndrome
• Venous thromboembolism (VTE)

Complete Differential Diagnosis of the causes of Leg pain

(By organ system)

Cardiovascular	Aortoiliac occlusive disease,Cholesterol Emboli Syndrome,Deep Vein Thrombosis,Peripheral Arterial Disease,Thrombophlebitis,Varicose veins
Chemical / poisoning	No underlying causes
Dermatologic	Behect's disease
Drug Side Effect	Abatacept Injection,Acebutolol,Acitretin,Aldesleukin,Alendronate,Allopurinol,Amikacin Sulfate Injection,Anagrelide,Anastrozole,Aripiprazole,Atazanavir,Atenolol,Atorvastatin,Bevacizumab Injection,Bortezomib,Buspirone,Capecitabine,Celecoxib,Celiac disease,Clofarabine Injection,Clonazepam,Clopidogrel,Cortisol,Darbepoetin Alfa,Docetaxel,Epoetin Alfa Injection,Ethacrynic Acid,Etidronate,Ezetimibe,Fenofibrate,Filgrastim,Fluvastatin,Gabapentin,Galantamine,Glatiramer Injection,Ibandronate,Iloprost,Imatinib,Infliximab Injection,Interferon Alfa-2a and Alfa-2b Injection,Interferon Alfacon-1 Injection,Interferon beta-1a Intramuscular Injection,Interferon Beta-1b Injection,Interferon Gamma-1b Injection,Lamivudine,Latanoprost,Leflunomide,Letrozole,Leuprolide,Lovastatin,Methimazole,Methylergonovine,Methylprednisolone,Mifepristone,Natalizumab injection ,Ofloxacin ,Paclitaxel,Peginterferon alfa-2a,Prednisone,Pyrazinamide,Quinupristin dalfopristin,Ribavirin,Rofecoxib,Rosiglitazone,Rosuvastatin,Sunitinib ,Tadalafil ,Tamsulosin ,Telbivudine ,Temozolomide ,Terbutaline,Teriparatide,Tiotropium,Torsemide,Valganciclovir,Valsartan,Vancomycin,Vinblastine,Vincristine,Zalcitabine,Ziprasidone,Zolmitriptan,Zolpidem,
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism,Primary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Ulcerative colitis
Genetic	Fairbanks disease,Familial Mediterranean fever,Mitochondrial trifunctional protein deficiency,Osteogenesis imperfecta,Hereditary multiple exostoses,Recessive multiple epiphyseal dysplasia,Farber disease
Hematologic	Erdheim-Chester disease,Leukemia,Lymphangiomatosis,Multiple myeloma,Phlebitis,Phlegmasia cerulea dolens,Thrombocytosis,Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia
Iatrogenic	No underlying causes
Infectious Disease	Bacterial : Cellulitis,Q Fever,Lassa Fever,Lemierre's Syndrome Viral : Parvovirus,Poliomyelitis,Rocky Mountain spotted fever,Acquired Immune Deficiency Syndrome
Musculoskeletal / Ortho	Athlete's foot,Baker's cyst,Bone tumor,Buerger's disease,Chondroblastoma,Chondromalacia patellae,Chondrosarcoma,Gout,Hereditary multiple exostoses,Ledderhose's disease,Legg-Calve-Perthes syndrome,Morton's toe,Myofascial Pain Syndrome,Myositis ossificans,Osteochondrosis,Paget's disease of bone,Pes anserinus (leg),Pigmented villonodular synovitis,Prepatellar bursitis,Recessive multiple epiphyseal dysplasia,Retropatellar Pain Syndrome,Sciatica,Synovial osteochondromatosis,Tenosynovitis,Erythromelagia,Ewing's sarcoma,Giant cell tumor of bone,Osteoporosis,Still's disease,Fairbanks disease,Osteogenesis imperfecta
Neurologic	Amyotrophic Lateral Sclerosis,Anterior spinal artery syndrome,Erythromelagia,Meralgia paraesthetica,Peripheral Neuropathy
Nutritional / Metabolic	Acute Intermittent Porphyria,Farber disease,Glycogen storage disease type V,Hypercalcemia,Mucopolysaccharidosis,Osteomalacia
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Ewing's sarcoma,Giant cell tumor of bone,Osteochondroma,Osteoma,Osteosarcoma,Leukemia,Lymphangiomatosis,Chondroblastoma,Chondrosarcoma
Opthalmologic	Behect's disease
Overdose / Toxicity	No underlying causes
Psychiatric	Pain disorder
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcemia
Rheum / Immune / Allergy	Rheumatology : Ankylosing Spondylitis,Behect's disease,Caplan's Syndrome,Fibromyalgia,Osteoarthritis,Osteoporosis,Polymyalgia Rheumatica,Rheumatoid arthritis,Still's disease, Gout Immunology : Systemic lupus erythematosus,Ulcerative colitis,Vasculitis,Graft-versus-host disease,Familial Mediterranean fever
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Phantom pain

(In alphabetical order):

1. Abatacept Injection 2. Acebutolol 3. Acitretin 4. Acquired Immune Deficiency Syndrome 5. Acute Intermittent Porphyria 6. Acute lymphoblastic leukemia 7. Acute myeloid leukemia 8. Acute promyelocytic leukemia 9. Aldesleukin 10. Alendronate 11. Allopurinol 12. Amikacin Sulfate Injection 13. Amyotrophic Lateral Sclerosis 14. Anagrelide 15. Anastrozole 16. Ankylosing Spondylitis 17. Anterior spinal artery syndrome 18. Aortoiliac occlusive disease 19. Aripiprazole 20. Atazanavir 21. Atenolol 22. Athlete's foot 23. Atorvastatin 24. Baker's cyst 25. Behect's disease 26. Bevacizumab Injection 27. Bone tumor 28. Bortezomib 29. Buerger's disease 30. Buspirone 31. Capecitabine 32. Caplan's Syndrome 33. Celecoxib 34. Celiac disease 35. Cellulitis 36. Cholesterol Emboli Syndrome 37. Chondroblastoma 38. Chondromalacia patellae 39. Chondrosarcoma 40. Clofarabine Injection 41. Clonazepam 42. Clopidogrel 43. Cortisol 44. Darbepoetin Alfa Injection 45. Deep Vein Thrombosis 46. Docetaxel 47. Epoetin Alfa Injection 48. Erdheim-Chester disease 49. Erythromelagia 50. Ethacrynic Acid 51. Etidronate 52. Ewing's sarcoma 53. Ezetimibe 54. Fairbanks disease 55. Familial Mediterranean fever 56. Farber disease 57. Fenofibrate 58. Fibromyalgia 59. Filgrastim 60. Fluvastatin 61. Gabapentin 62. Galantamine 63. Giant cell tumor of bone 64. Glatiramer Injection 65. Glycogen storage disease type V 66. Gout 67. Graft-versus-host disease 68. Hereditary multiple exostoses 69. Hypercalcemia 70. Hypercalcemia 71. Hyperparathyroidism 72. Ibandronate 73. Iloprost 74. Imatinib 75. Infliximab Injection 76. Interferon Alfa-2a and Alfa-2b Injection 77. Interferon Alfacon-1 Injection 78. Interferon beta-1a Intramuscular Injection 79. Interferon Beta-1b Injection 80. Interferon Gamma-1b Injection 81. Lamivudine 82. Lassa Fever 83. Latanoprost 84. Ledderhose's disease 85. Leflunomide 86. Legg-Calve-Perthes syndrome 87. Lemierre's Syndrome 88. Letrozole 89. Leukemia 90. Leuprolide 91. Lovastatin 92. Lymphangiomatosis 93. Meralgia paraesthetica 94. Methimazole 95. Methylergonovine Oral 96. Methylprednisolone Oral 97. Mifepristone 98. Mitochondrial trifunctional protein deficiency 99. Morton's toe 100. Mucopolysaccharidosis 101. Multiple myeloma 102. Myofascial Pain Syndrome 103. Myositis ossificans 104. Natalizumab injection 105. Ofloxacin 106. Osteoarthritis 107. Osteochondroma 108. Osteochondrosis 109. Osteogenesis imperfecta 110. Osteoma 111. Osteomalacia 112. Osteoporosis 113. Osteosarcoma 114. Paclitaxel 115. Paget's disease of bone 116. Pain disorder 117. Parvovirus 118. Peginterferon alfa-2a 119. Peripheral Arterial Disease 120. Peripheral Neuropathy 121. Pes anserinus (leg) 122. Phantom pain 123. Phlebitis 124. Phlegmasia cerulea dolens 125. Pigmented villonodular synovitis 126. Poliomyelitis 127. Polymyalgia Rheumatica 128. Prednisone 129. Prepatellar bursitis 130. Primary hyperparathyroidism 131. Pyrazinamide 132. Q Fever 133. Quinupristin and dalfopristin injection 134. Recessive multiple epiphyseal dysplasia 135. Retropatellar Pain Syndrome 136. Rheumatoid arthritis 137. Ribavirin 138. Rocky Mountain spotted fever 139. Rofecoxib 140. Rosiglitazone 141. Rosuvastatin 142. Sciatica 143. Still's disease 144. Sunitinib 145. Synovial osteochondromatosis 146. Systemic lupus erythematosus 147. Tadalafil 148. Tamsulosin 149. Telbivudine 150. Temozolomide 151. Tenosynovitis 152. Terbutaline 153. Teriparatide (rDNA origin) Injection 154. Thrombocytosis 155. Thrombophlebitis 156. Tiotropium Oral Inhalation 157. Torsemide Injection 158. Ulcerative colitis 159. Valganciclovir 160. Valsartan 161. Vancomycin 162. Varicose veins 163. Vasculitis 164. Vinblastine 165. Vincristine 166. Zalcitabine 167. Ziprasidone 168. Zolmitriptan 169. Zolpidem

References

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