Osteoporosis future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Raviteja Guddeti, M.B.B.S.[3]
Overview
Recent advances in the field of bone biology have led to a better understanding of bone cell functions and crosstalk between osteoblasts, osteoclasts, and osteocytes at the molecular level. Research is under way to discover new therapies to reduce the fracture risk in the osteoporotic population.
Future investigational therapies
These include
- New bone anabolic substances such as antibodies directed against the endogenous inhibitors of bone formation sclerostin and dickkopf-1, PTH and PTHrp analogues, and possibly calcilytics
- New inhibitors of bone resorption such as cathepsin K inhibitors which may suppress osteoclast function without impairing osteoclast viability and thus maintain bone formation by preserving the osteoclast-osteoblast crosstalk, and denosumab[1], an already widely available antibody against RANKL which inhibits osteoclast formation, function, and survival
- Sequential therapies with two or more bone active substances aimed at optimizing the management of bone capital acquired during adolescence and maintained during adulthood in terms of both quantity and quality.[2]
References
- ↑ McClung MR, Lewiecki EM, Geller ML; et al. (2012). "Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trial". Osteoporos Int. doi:10.1007/s00198-012-2052-4. PMID 22776860. Unknown parameter
|month=ignored (help) - ↑ Lippuner K (2012). "The future of osteoporosis treatment - a research update". Swiss Med Wkly. 142. doi:10.4414/smw.2012.13624. PMID 22815185.