Cerebral venous sinus thrombosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: : Kalsang Dolma, M.B.B.S.[2]

Cerebral venous sinus thrombosis is more common in particular situations. 85% of patients have at least one of these risk factors:^[1]

Thrombophilia (a tendency to develop blood clots due to abnormalities in coagulation, e.g. deficiency of protein C, protein S, antithrombin or related problems)
Nephrotic syndrome (a kidney problem causing protein loss in the urine)
Chronic inflammatory diseases (inflammatory bowel disease, lupus, Behçet's disease)
Pregnancy and puerperium (the period after giving birth)
Particular blood disorders, especially polycythemia vera and paroxysmal nocturnal hemoglobinuria
Use of the contraceptive pill
Meningitis and infections of the ear, nose and throat area (mastoiditis, sinusitis)
Direct injury to the venous sinuses, and medical procedures in the area

Other less well understood situations that increase the risk for cerebral sinus thrombosis are hyperthyroidism^[2] and myelodysplastic syndrome.^[3]

References

↑ Stam J (2005). "Thrombosis of the cerebral veins and sinuses". N. Engl. J. Med. 352 (17): 1791–8. doi:10.1056/NEJMra042354. PMID 15858188.
↑ Dai A, Wasay M, Dubey N, Giglio P, Bakshi R (2000). "Superior sagittal sinus thrombosis secondary to hyperthyroidism". Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 9 (2): 89–90. doi:10.1053/jscd.2000.0090089. PMID 17895204.
↑ Finelli PF, Harrison RB, Uphoff DF (1998). "Myelodysplastic syndrome and sagittal sinus thrombosis". Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 7 (3): 211–2. PMID 17895084.