Adrenocortical carcinoma pathophysiology
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Differentiating Adrenocortical carcinoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Adrenocortical carcinoma may be linked to a cancer syndrome that is passed down through families (inherited).
This tumor can produce the hormones cortisol, aldosterone, estrogen, or testosterone, as well as other hormones. In women the tumor often releases these hormones, which can lead to male characteristics.
Studies suggest that mutations of the tumor suppressor genes TP53 and TP57 might also be contributing factors for development of Adrenocortical carcinoma.