Milroy's Disease

Jump to navigation Jump to search

WikiDoc Resources for Milroy's Disease

Articles

Most recent articles on Milroy's Disease

Most cited articles on Milroy's Disease

Review articles on Milroy's Disease

Articles on Milroy's Disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Milroy's Disease

Images of Milroy's Disease

Photos of Milroy's Disease

Podcasts & MP3s on Milroy's Disease

Videos on Milroy's Disease

Evidence Based Medicine

Cochrane Collaboration on Milroy's Disease

Bandolier on Milroy's Disease

TRIP on Milroy's Disease

Clinical Trials

Ongoing Trials on Milroy's Disease at Clinical Trials.gov

Trial results on Milroy's Disease

Clinical Trials on Milroy's Disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Milroy's Disease

NICE Guidance on Milroy's Disease

NHS PRODIGY Guidance

FDA on Milroy's Disease

CDC on Milroy's Disease

Books

Books on Milroy's Disease

News

Milroy's Disease in the news

Be alerted to news on Milroy's Disease

News trends on Milroy's Disease

Commentary

Blogs on Milroy's Disease

Definitions

Definitions of Milroy's Disease

Patient Resources / Community

Patient resources on Milroy's Disease

Discussion groups on Milroy's Disease

Patient Handouts on Milroy's Disease

Directions to Hospitals Treating Milroy's Disease

Risk calculators and risk factors for Milroy's Disease

Healthcare Provider Resources

Symptoms of Milroy's Disease

Causes & Risk Factors for Milroy's Disease

Diagnostic studies for Milroy's Disease

Treatment of Milroy's Disease

Continuing Medical Education (CME)

CME Programs on Milroy's Disease

International

Milroy's Disease en Espanol

Milroy's Disease en Francais

Business

Milroy's Disease in the Marketplace

Patents on Milroy's Disease

Experimental / Informatics

List of terms related to Milroy's Disease

Milroy's disease
ICD-10 Q82.0
ICD-9 757.0
OMIM 153100
DiseasesDB 8228
eMedicine med/1482 
MeSH D008209

WikiDoc Resources for Milroy's Disease

Articles

Most recent articles on Milroy's Disease

Most cited articles on Milroy's Disease

Review articles on Milroy's Disease

Articles on Milroy's Disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Milroy's Disease

Images of Milroy's Disease

Photos of Milroy's Disease

Podcasts & MP3s on Milroy's Disease

Videos on Milroy's Disease

Evidence Based Medicine

Cochrane Collaboration on Milroy's Disease

Bandolier on Milroy's Disease

TRIP on Milroy's Disease

Clinical Trials

Ongoing Trials on Milroy's Disease at Clinical Trials.gov

Trial results on Milroy's Disease

Clinical Trials on Milroy's Disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Milroy's Disease

NICE Guidance on Milroy's Disease

NHS PRODIGY Guidance

FDA on Milroy's Disease

CDC on Milroy's Disease

Books

Books on Milroy's Disease

News

Milroy's Disease in the news

Be alerted to news on Milroy's Disease

News trends on Milroy's Disease

Commentary

Blogs on Milroy's Disease

Definitions

Definitions of Milroy's Disease

Patient Resources / Community

Patient resources on Milroy's Disease

Discussion groups on Milroy's Disease

Patient Handouts on Milroy's Disease

Directions to Hospitals Treating Milroy's Disease

Risk calculators and risk factors for Milroy's Disease

Healthcare Provider Resources

Symptoms of Milroy's Disease

Causes & Risk Factors for Milroy's Disease

Diagnostic studies for Milroy's Disease

Treatment of Milroy's Disease

Continuing Medical Education (CME)

CME Programs on Milroy's Disease

International

Milroy's Disease en Espanol

Milroy's Disease en Francais

Business

Milroy's Disease in the Marketplace

Patents on Milroy's Disease

Experimental / Informatics

List of terms related to Milroy's Disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S

Synonyms and keywords: Milroy's syndrome; Nonne-Milroy-Meige syndrome; Hereditary lymphedema

Overview

Milroy's disease is a familial disease characterised by lymphedema, commonly in the legs, caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid accumulation and hypertrophy of soft tissues.[1][2]

Historical Perspective

It was named by Sir William Osler for William Milroy, an American physician, who described a case in 1892, though it was first described by Rudolf Virchow in 1863.[3][4]

Pathophysiology

Genetics

An association with the gene FLT4 has been described.[5]

Epidemiology and Demographics

This disease is more common in women.

Natural History, Complications, Prognosis

The defect in Milroy's disease is present from birth and symptoms are usually first experienced in childhood.

Diagnosis

Symptoms

  • Unilateral leg edema: The most common problem is one-sided leg swelling, unilateral edema, which is progressive and can affect both legs.

Laboratory Findings

Defective lymphocyte circulation can cause lymphopenia and impaired cell-mediated immunity.

External links

References

  1. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 849. ISBN 0-7216-2921-0.
  2. David Lowell Strayer; Raphael Rubin (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th Edition. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-9516-8.
  3. Template:WhoNamedIt
  4. W. F. Milroy. An undescribed variety of herditary edema. New York Medical Journal, 1892, 56: 505-508.
  5. Spiegel R, Ghalamkarpour A, Daniel-Spiegel E, Vikkula M, Shalev SA (2006). "Wide clinical spectrum in a family with hereditary lymphedema type I due to a novel missense mutation in VEGFR3". Journal of human genetics. 51 (10): 846–50. doi:10.1007/s10038-006-0031-3. PMID 16924388.

Template:WH Template:WS