CYP4F12
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cytochrome P450, family 4, subfamily F, polypeptide 12, also known as CYP4F12, is a human gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxidizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.[1]
References
Further reading
- Simpson AE (1997). "The cytochrome P450 4 (CYP4) family". Gen. Pharmacol. 28 (3): 351–9. PMID 9068972.
- Knight JA, Fronk S, Haymond RE (1975). "Chemical basis and specificity of chemical screening tests for urinary vanilmandelic acid". Clin. Chem. 21 (1): 130–3. PMID 1116264.
- Bylund J, Bylund M, Oliw EH (2001). "cDna cloning and expression of CYP4F12, a novel human cytochrome P450". Biochem. Biophys. Res. Commun. 280 (3): 892–7. doi:10.1006/bbrc.2000.4191. PMID 11162607.
- Hashizume T, Imaoka S, Hiroi T; et al. (2001). "cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine". Biochem. Biophys. Res. Commun. 280 (4): 1135–41. doi:10.1006/bbrc.2000.4238. PMID 11162645.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Stark K, Wongsud B, Burman R, Oliw EH (2005). "Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8". Arch. Biochem. Biophys. 441 (2): 174–81. doi:10.1016/j.abb.2005.07.003. PMID 16112640.
- Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.