Amyloidosis natural history, complications and prognosis

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Classification • Primary amyloidosis • Secondary amyloidosis • Familial amyloidosis • Wild-type (senile) amyloidosis • Cardiac amyloidosis • Beta-2 microglobulin related amyloidosis • Gelsolin related amyloidosis • Lysozyme amyloid related amyloidosis • Leucocyte cell-derived chemotaxin 2 related amyloidosis • Fibrinogen A alpha-chain associated amyloidosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Complications

Possible complications of amyloidosis include:

• Hyposplenism
• Malabsorption syndrome
• Myopathy
• Proximal renal tubular acidosis
• Renal failure
• Vascular hemostatic disorder
• Chronic brain failure
• Nephrotic syndrome
• Myocarditis
• Restrictive cardiomyopathy
• Pulmonary fibrosis
• Autonomic neuropathy
• Pericardial effusion
• Congestive heart failure
• Endocrine failure (hormonal disorder)
• Respiratory failure
• Hypogonadic hypogonadism
• Death

Prognosis

The severity the disease depends on the organs that are affected. When the heart and kidney are involved, it may lead to organ failure and death. Body-wide (systemic) involvement can lead to death in 1 to 3 years.