Henoch-Schönlein purpura other diagnostic studies
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Differentiating Henoch-Schönlein purpura from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Biopsy
If there is doubt about the cause of the skin lesions, a biopsy of the skin may be performed to distinguish the purpura from other diseases that cause purpura (such as vasculitis due to cryoglobulinemia); on microscopy the appearances are of a hypersensitivity vasculitis and immunofluorescence demonstrates IgA and C3 (a protein of the complement system) in the blood vessel wall. Biopsy of the kidney may be performed both to establish the diagnosis or to assess the severity of already suspected kidney disease. The main findings on kidney biopsy are increased cells in the mesangium (part of the glomerulus, where blood is filtered), white blood cells, and the development of crescents. The changes are indistinguishable from those observed IgA nephropathy.[1]
References
- ↑ Rai A, Nast C, Adler S (1999). "Henoch-Schönlein purpura nephritis". J. Am. Soc. Nephrol. 10 (12): 2637–44. PMID 10589705.