Paraesthesia pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Chronic paresthesia indicates a problem with the functioning of neurons. This malfunction, which is especially common in older individuals, is often the result of poor circulation in the limbs (such as in peripheral vascular disease), which may be caused by atherosclerosis — the build up of plaque on artery walls. Without a proper supply of blood and nutrients, nerve cells can no longer adequately send signals to the brain. Because of this, paresthesia can also be a symptom of vitamin deficiency and malnutrition, as well as metabolic disorders like diabetes, hypothyroidism, and hypoparathyroidism.
Irritation to the nerve can also come frhe surroom inflammation to tunding tissue. Joint conditions such as rheumatoid arthritis and carpal tunnel syndrome are common sources of paresthesia.
Another cause of paresthesia, however, may be direct damage to the nerves themselves, or neuropathy, which can stem from injury or infection such as Lyme disease, or which may be indicative of a current neurological disorder. Chronic paresthesia can sometimes be symptomatic of serious conditions, such as a transient ischemic attack, a brain tumor, motor neurone disease, or autoimmune disorders like multiple sclerosis or lupus erythematosus. A diagnostic evaluation by a doctor is necessary to rule these out.
Paresthesiae of the mouth, hands, and feet are common, transient symptoms of the related conditions of hyperventilation syndrome and panic attacks.