Brucellosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Symptoms
Acute brucellosis may begin with mild flu-like symptoms, or symptoms such as:
- Abdominal pain
- Back pain
- Chills
- Excessive sweating
- Fatigue
- Fever
- Headache
- Joint pain
- Loss of appetite
- Weakness
- Weight loss
- depression
High fever spikes usually occur every afternoon. The name "undulant" fever is because the fever rises and falls in waves.
Other symptoms that may occur with this disease:
- Muscle pain
- Swollen glands
The illness may be chronic and last for years.
In first stage of the disease, septicaemia occurs and leads to the classic triad of undulant fevers, sweating (often with characteristic smell, likened to wet hay) and migratory arthralgia and myalgia. In blood tests, is characteristic the leukopenia and anemia, some elevation of AST and ALT and positivity of classic Bengal Rose and Huddleson reactions. This complex is, at least in Portugal known as the Malta fever. During episodes of Malta fever, melitococcemia (presence of brucellae in blood) can usually be demonstrated by means of blood culture in tryptose medium or Albini medium. If untreated, the disease can give origin to focalizations or become chronic. The focalizations of brucellosis occur usually in bones and joints and spondylodisciitis of lumbar spine accompanied by sacroiliitis is very characteristic of this disease. Orchitis is also frequent in men.