Whipple's disease natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Complications

The following complications may be seen in cases of Whipple's disease.

• Brain damage
• Heart valve damage (from endocarditis)
• Nutritional deficiencies
• Symptoms return (which may be because of drug resistance)
• Weight loss

Prognosis

Without treatment, the condition is usually fatal. Treatment relieves symptoms and can cure the disease.