Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2gene.[1][2][3]
Function
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.[3]
References
↑Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (Oct 1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle". Hum Reprod. 10 (5): 1297–304. PMID7657783.
↑De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L (Mar 1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 240–1. doi:10.1159/000015191. PMID10072590.
van Eijk HG, Tio TH, Bos G (1975). "Iron in skin biopsies". Archiv für dermatologische Forschung. 251 (3): 245–8. PMID1115525.
Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. doi:10.1021/bi00144a014. PMID1322170.
Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID1654334.
Colantuoni V, Cortese R, Nilsson M, Lundvall J, Båvik CO, Eriksson U, Peterson PA, Sundelin J (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID2992469.
Demmer LA, Birkenmeier EH, Sweetser DA, Levin MS, Zollman S, Sparkes RS, Mohandas T, Lusis AJ, Gordon JI (1987). "The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene". J. Biol. Chem. 262 (6): 2458–67. PMID3029082.
Chan SW, Hong W (2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription". J. Biol. Chem. 276 (30): 28402–12. doi:10.1074/jbc.M100313200. PMID11358960.
Zhang L, E X, Luker KE, Shao JS, Levin MS, Suh E, Li E (2002). "Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (6): G1079–87. doi:10.1152/ajpgi.00041.2001. PMID12016134.
