SIPA1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Further reading

• Minato N (1997). "[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene]". Hum. Cell. 9 (1): 11–6. PMID 9183624.
• Hattori M, Tsukamoto N, Nur-e-Kamal MS, et al. (1995). "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression". Mol. Cell. Biol. 15 (1): 552–60. PMC 232010. PMID 7799964.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kurachi H, Wada Y, Tsukamoto N, et al. (1997). "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product". J. Biol. Chem. 272 (44): 28081–8. doi:10.1074/jbc.272.44.28081. PMID 9346962.
• Ebrahimi S, Wang E, Udar N, et al. (1998). "Genomic organization and cloning of the human homologue of murine Sipa-1". Gene. 214 (1–2): 215–21. doi:10.1016/S0378-1119(98)00212-1. PMID 9651531.
• Tsukamoto N, Hattori M, Yang H, et al. (1999). "Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion". J. Biol. Chem. 274 (26): 18463–9. doi:10.1074/jbc.274.26.18463. PMID 10373454.
• Hoecker U, Quail PH (2001). "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis". J. Biol. Chem. 276 (41): 38173–8. doi:10.1074/jbc.M103140200. PMID 11461903.
• Roy BC, Kohu K, Matsuura K, et al. (2003). "SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus". Genes Cells. 7 (6): 607–17. doi:10.1046/j.1365-2443.2002.00546.x. PMID 12059963.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization". Mol. Cell. Biol. 24 (20): 9059–69. doi:10.1128/MCB.24.20.9059-9069.2004. PMC 517877. PMID 15456879.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Crawford NP, Ziogas A, Peel DJ, et al. (2006). "Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer". Breast Cancer Res. 8 (2): R16. doi:10.1186/bcr1389. PMC 1483843. PMID 16563182.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.