TFDP1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]

Interactions

TFDP1 has been shown to interact with:

• E2F1,
• E2F5, and
• P53.

Further reading

• Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
• Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
• Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes Dev. 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924.
• Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo". Genes Dev. 8 (22): 2680–90. doi:10.1101/gad.8.22.2680. PMID 7958925.
• Bandara LR, Lam EW, Sørensen TS, Zamanian M, Girling R, La Thangue NB (1994). "DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein". EMBO J. 13 (13): 3104–14. PMC 395201. PMID 8039504.
• Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. PMID 8405995.
• Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
• Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. 16 (10): 5888–95. doi:10.1128/mcb.16.10.5888. PMC 231590. PMID 8816502.
• Vidal M, Braun P, Chen E, Boeke JD, Harlow E (1996). "Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10321–6. doi:10.1073/pnas.93.19.10321. PMC 38382. PMID 8816798.
• Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". J. Cell Sci. 109. ( Pt 7): 1717–26. PMID 8832394.
• Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.
• Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179.
• Cartwright P, Müller H, Wagener C, Holm K, Helin K (1998). "E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription". Oncogene. 17 (5): 611–23. doi:10.1038/sj.onc.1201975. PMID 9704927.
• Timchenko NA, Wilde M, Darlington GJ (1999). "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice". Mol. Cell. Biol. 19 (4): 2936–45. PMC 84088. PMID 10082561.
• Lam EW, Glassford J, van der Sman J, Banerji L, Pizzey AR, Shaun N, Thomas B, Klaus GG (1999). "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors". Eur. J. Immunol. 29 (10): 3380–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C. PMID 10540350.
• Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
• Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.