Cirrhosis classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Charmaine Patel, M.D. [2]
Overview
Classification Based on Morphology
Cirrhosis has historically been classified upon the nodular morphology that is seen on upon the gross appearance of the liver. Accurate assessment of the liver morphology can only be obtained through surgery, biopsy, or autopsy, therefore more recently, more non-invasive means of classifying and determining the causes of cirrhosis are used.
Micronodular
Micronodular cirrhosis is characterized by nodules that are less than 3mm in diameter, and is caused by:
- Alcohol
- Hemochromatosis
- Cholestatic causes of cirrhosis
- Hepatic venous outflow obstruction
Macronodular
Macronodular cirrhosis is characterized by nodules that are more than 3mm in diameter, and is usually due to chronic viral hepatitis.
Mixed
It has been shown that micronodular cirrhosis can often progress into macronodular cirrhosis. During this transformation, a mixed form of cirrhosis may be seen. [1]
References
- ↑ Fauerholdt L, Schlichting P, Christensen E, Poulsen H, Tygstrup N, Juhl E (1983). "Conversion of micronodular cirrhosis into macronodular cirrhosis". Hepatology. 3 (6): 928–31. PMID 6629323.