Iron deficiency anemia pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Physiology
- In the human body, iron is present in all cells and has several vital functions such as:
- A carrier of oxygen to the tissues from the lungs in the form of hemoglobin (Hb)
- Facilitator of oxygen use and storage in the muscles as myoglobin
- Transport medium for electrons within the cells in the form of cytochromes
- Integral part of enzyme reactions in various tissues.
Pathophysiology
Iron deficiency (sideropenia) is the most common known form of nutritional deficiency. Too little iron can interfere with these vital functions and lead to morbidity and mortality. The direct consequence of iron deficiency is iron deficiency anemia. Groups that are most prone to developing this disease are children and pre-menopausal women.