Macrocytic anemia risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk Factors
- Folate deficiency
- Nutritionally deficient - Elderly, alcohol, narcotic abuse
- Those with increased demand: pregnancy, infancy, low grade hemolysis, malignancy or chronic hemodialysis.
- Pernicious Anemia (PA) is the most common cause of B12 deficiency in the US and is associated with other autoimmune disease such as Hashimoto’s, vitiligo, diabetes, adrenal insufficiency, etc. (Schmitt’s Syndrome).
- Strict Vegans and/or their infants can become B12 deficient from poor intake.
- Patients with malabsorptive disorders such as blind loops/bacterial overgrowth, Sprue, Whipple’s and Crohn’s can malabsorb folate and B12. D.Latum is a competitor for B12 absorption. This entity is most commonly found in Scandinavia.