Macrocytic anemia history and symptoms

Macrocytic anemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Macrocytic anemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Macrocytic anemia history and symptoms On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Macrocytic anemia history and symptoms All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Macrocytic anemia history and symptoms
CDC on Macrocytic anemia history and symptoms
Macrocytic anemia history and symptoms in the news
Blogs on Macrocytic anemia history and symptoms
Directions to Hospitals Treating Macrocytic anemia
Risk calculators and risk factors for Macrocytic anemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

The following points should be noted in history:

• Patient age: MCV is higher in neonates and infants.
• Medical history
• Alcohol use
• Medications (eg, anticonvulsants, zidovudine, immunosuppressive agents) – 51 (35 percent)
• Congenital heart disease – 20 (14 percent)
• Down syndrome – 12 (8 percent)
• Reticulocytosis – 11 (8 percent)
• Bone marrow failure/dysplasia – 6 (4 percent)
• Liver disease, thyroid disease [21,47]
• Hemolytic anemias with reticulocytosis and myelodysplastic syndromes (MDS)
• Macrocytosis is a common feature of MDS, especially in older adults

Patients usally show the following symptoms:

• B12 deficiency causes neurologic dysfunction.
• Anemia symptoms such as fatigue, dyspnea, lightheadedess, and anorexia occur

• High output cardiac failure
• Angina
• Diarrhea
• Cheilosis
• Glossitis
• Subacute combined degeneration of the dorsal columns.
• Broad based gait
• Ataxic
• Numbness or paresthesias.
• Rhomberg and Babinski’s sign.
• Dementia may progress to frank “Megaloblastic Madness”