Delta-thalassemia

Delta-thalassemia
ICD-9	282.4
MeSH	D055538

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Delta-thalassemia is a form of thalassemia. It is associated with HBD.

Relationship to beta thalassemia

The importance of recognizing the existence of delta thalassemia is seen best in cases where it may mask the diagnosis of beta thalassemia trait. In beta thalassemia, there is an increase in hemoglobin A2, typically in the range of 4-6% (normal is 2-3%). However, the co-existence of a delta thalassemia mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia trait. This can be important in genetic counseling, because a child who is the product of parents each of whom has beta⁰ thalassemia trait has a one in four chance of having beta thalassemia major.

References

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