Hemolytic anemia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

It has numerous possible causes, ranging from relatively harmless to life-threatening.

Causes

Common Causes

• Hemolytic anemia occurs when the bone marrow is unable to increase production to make up for the premature destruction of red blood cells.
• If the bone marrow is able to keep up with the early destruction, anemia does not occur (this is sometimes called compensated hemolysis).
• There are many types of hemolytic anemia, which are classified by the reason for the premature destruction of red blood cells. The defect may be in the red blood cell itself (intrinsic factors), or outside the red blood cell (extrinsic factors).

Intrinsic or Intracorpuscular

• Commonly hereditary exceptions, paroxysmal nocturnal hemoglobinuria and acquired alpha thalassemia
• Abnormalities in the proteins that build normal red blood cells
• Differences in the protein inside a red blood cell that carries oxygen (hemoglobin)

Extrinsic factors

• Commonly acquired
• Abnormal immune system responses
• Blood clots in small blood vessels
• Certain infections
• Side effects from medications