Yersinia pestis infection causes

Revision as of 15:59, 26 September 2012 by Esther Lee (talk | contribs)
Jump to navigation Jump to search

Template:Yersinia Pestis Infection Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editors-In-Chief: Esther Lee, M.A.

Overview

Causes

Yersinia pestis, a rod-shaped facultative anaerobe with bipolar staining (giving it a safety pin appearance).[1] causes the infection in mammals and humans.

Transmission of Y. pestis to an uninfected individual is possible by any of the following means.[2]

  • droplet contact – coughing or sneezing on another person
  • direct physical contact – touching an infected person, including sexual contact
  • indirect contact – usually by touching soil contamination or a contaminated surface
  • airborne transmission – if the microorganism can remain in the air for long periods
  • fecal-oral transmission – usually from contaminated food or water sources
  • vector borne transmission – carried by insects or other animals.

Genome

The complete genomic sequence is available for two of the three sub-species of yersinia pestis: strain KIM (of biovar Medievalis),[3] and strain CO92 (of biovar Orientalis, obtained from a clinical isolate in the United States).[4] As of 2006, the genomic sequence of a strain of biovar Antiqua has been recently completed.[5] Similar to the other pathogenic strains, there are signs of loss of function mutations. The chromosome of strain KIM is 4,600,755 base pairs long; the chromosome of strain CO92 is 4,653,728 base pairs long. Like its cousins Yersinia pseudotuberculosis and Yersinia enterocolitica, Yersinia pestis is host to the plasmid pCD1. In addition, it also hosts two other plasmids, pPCP1 (also called pPla or pPst) and pMT1 (also called pFra) that are not carried by the other Yersinia species. pFra codes for a phospholipase D that is important for the ability of Yersinia pestis to be transmitted by fleas.[6] pPla codes for a protease, Pla, that activates plasminogen in human hosts and is a very important virulence factor for pneumonic plague.[7] Together, these plasmids, and a pathogenicity island called HPI, encode several proteins that cause the pathogenesis, for which Yersinia pestis is famous. Among other things, these virulence factors are required for bacterial adhesion and injection of proteins into the host cell, invasion of bacteria in the host cell (via a Type III secretion system), and acquisition and binding of iron that is harvested from red blood cells (via siderophores). Yersinia pestis is thought to be descendant from Yersinia pseudotuberculosis, differing only in the presence of specific virulence plasmids.

A comprehensive and comparative proteomics analysis of Yersinia pestis strain KIM was performed in 2006.[8] The analysis focused on the transition to a growth condition mimicking growth in host cells.

References

  1. ↑ Collins FM (1996). Pasteurella, Yersinia, and Francisella. In: Baron's Medical Microbiology (Baron S et al, eds.) (4th ed.). Univ. of Texas Medical Branch. ISBN 0-9631172-1-1.
  2. ↑ Plague Manual: Epidemiology, Distribution, Surveillance and Control, pp. 9 and 11. WHO/CDS/CSR/EDC/99.2
  3. ↑ Deng W; et al. (2002). "Genome Sequence of Yersinia pestis KIM". Journal of Bacteriology. 184 (16): 4601&ndash, 4611. doi:10.1128/JB.184.16.4601-4611.2002. PMC 135232. PMID 12142430. Unknown parameter |author-separator= ignored (help)
  4. ↑ Parkhill J; et al. (2001). "Genome sequence of Yersinia pestis, the causative agent of plague". Nature. 413 (6855): 523&ndash, 527. doi:10.1038/35097083. PMID 11586360. Unknown parameter |author-separator= ignored (help)
  5. ↑ Chain PS; Hu P; Malfatti SA; et al. (2006). "Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal516: Evidence of Gene Reduction in an Emerging Pathogen". J. Bacteriol. 188 (12): 4453–63. doi:10.1128/JB.00124-06. PMC 1482938. PMID 16740952. Unknown parameter |author-separator= ignored (help)
  6. ↑
  7. ↑
  8. ↑ Hixson K; et al. (2006). "Biomarker candidate identification in Yersinia pestis using organism-wide semiquantitative proteomics". Journal of Proteome Research. 5 (11): 3008–3017. doi:10.1021/pr060179y. PMID 16684765. Unknown parameter |author-separator= ignored (help)

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Yersinia_pestis_infection_causes&oldid=757511"