Ketoacidosis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Ketoacidosis occurs when cells do not have sufficient glucose to meet their metabolic demands. Instead, ketone bodies are produced for energy via the metabolism of fatty acids. Acidity results from the dissociation of the H⁺ ion at physiological pH of metabolic ketone bodies such as acetoacetate, and β-hydroxybutyrate.