Brugada syndrome diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The diagnosis of brugada syndrome is based upon electrocardiographic and clinical criteria.

Diagnostic criteria

1. The presence of Type 1 ST-segment elevation in more than one right precordial lead (_V1-V₃). Type I ST elevation can be observed either spontaneously or following the administration of a sodium channel blocking agent.
2. One or more of the following criteria must also be met:

• Family history of sudden cardiac death (SCD) (<45 years old)
• Documented ventricular fibrillation (VF)
• Polymorphic ventricular tachycardia
• Coved-type ECG changes in family members
• Inducibility of ventricular tachycardia (VT) with programmed electrical stimulation (PES)

1. The diagnosis is also considered positive when a Type 2 (saddleback pattern) or Type 3 ST-segment elevation is observed in more than one right precordial lead under baseline conditions and can be converted to the diagnostic Type 1 pattern occurs upon exposure to a sodium channel blocker.