Noma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Noma is a rapidly progressive, polymicrobial, opportunistic infection that occurs during periods of compromised immune function. Fusobacterium necrophorum and Prevotella intermedia are thought to be key players in the process and interact with one or more other bacterial organisms (such as Borrelia vincentii, Porphyromonas gingivalis, Tannerella forsynthesis, Treponema denticola, Staphylococcus aureus, and nonhemolytic Streptococcus spp).[1]
Causes
Many children who develop the disease have had another illness such as measles, scarlet fever, tuberculosis, cancer, or immunodeficiency. Although the exact cause is not known, poor nutrition is a risk factor for the disease. It is not communicable.
The reported predisposing factors include:[1]
- Malnutrition or dehydration
- Poor oral hygiene
- Poor sanitation
- Unsafe drinking water
- Proximity to unkempt livestock
- Recent illness
- Malignancy
- An immunodeficiency disorder, including AIDS
In many cases a recent debilitating illness, usually measles and sometimes herpes simplex, varicella (chicken pox), scarlet fever, malaria, tuberculosis, gastroenteritis or bronchopneumonia, precedes the appearance of noma as well as cancers such as leukemia.[1] In many instances the infection begins as necrotizing ulcerative gingivitis (NUG). Early presentation is unclear as noma is often well progressed at initial presentation.[1]
Noma, unlike most infections, is able to spread through anatomic barriers such as muscle.[1]
In the developed world, noma has virtually disappeared except for an occasional case related to immunosuppressive conditions such as HIV infection, severe combined immunodeficiency syndrome, or intense immunosuppressive therapy.[1]