Cavernous angioma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
The incidence in the general population is between 0.1–0.5%, and clinical symptoms typically appear between 30 to 50 years of age. Once thought to be strictly congenital, these vascular lesions have been found to occur de novo.
Incidence
The incidence in the general population is between 0.1–0.5%.
Prevalence
With the advent of MRI, cavernous malformation are currently the most commonly identified brain vascular malformations.
Multiple lesions are seen in approximately 15-33% of spontaneous cases.
A familial form of the disorder exists and is inherited as an autosomal dominant trait with variable expression. Multiple lesions are more common in the familial form, occurring in as many as 73% of patients.
Cavernous malformations also appear to be the most common CNS vascular malformation subtype in patients with mixed lesions. The most common combination include a developmental venous anomaly, which is identified in approximately 10-30% of patients with cavernous angiomas.
Age
Cavernous malformations can occur at any age, but they are most likely to become clinically apparent in patients aged 20-40 years.