Donovanosis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]

Laboratory Findings

• It may be donovanosis if genital sores have been present for a long time and have been spreading.

• Tests that may be done include:
  • Culture of tissue sample: Culture of C. granulomatis is difficult to perform and not routinely available.
  • Scrapings or punch biopsy of lesion: Diagnosis requires visualization of Donovan bodies (numerous bacilli in the cytoplasm of macrophage demonstrated with Giemsa or Wright’s stain) in smears of scrapings from the ulcer base or histologic sections.

• Laboratory tests, such as those used to detect syphilis, are available only on a research basis for diagnosing donovanosis.