Bubonic plague medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Antibiotics of choice for bubonic plague include streptomycin, chloramphenicol, tetracycline, gentamycin and doxycycline.
Medical Therapy
Pharmacotherapy
Acute Pharmacotherapies
Vladimir Havkin, an Indian doctor of Russian-Jewish origin, was the first to invent and test a plague antibiotic. The traditional treatments are:
- Streptomycin 30 mg/kg IM twice daily for 7 days
- Chloramphenicol 25–30 mg/kg single dose, followed by 12.5–15 mg/kg four times daily
- Tetracycline 2 g single dose, followed by 500 mg four times daily for 7–10 days (not suitable for children)
More recently,
- Gentamicin 2.5 mg/kg IV or IM twice daily for 7 days
- Doxycycline 100 mg (adults) or 2.2 mg/kg (children) orally twice daily have also been shown to be effective.[1]
References
- ↑ Mwengee W; et al. (2006). "Treatment of Plague with Genamicin or Doxycycline in a Randomized Clinical Trial in Tanzania". Clin Infect Dis. 42 (5): 614&ndash, 21.