Enterobiasis medical therapy
Template:PinwormEditor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The condition can be treated with mebendazole (Vermox), albendazole, piperazine (Antepar), or mostly commonly pyrantel pamoate (Combatrin, Povan). Taking a second dose of medication two weeks after the first will usually kill any pinworms that might have hatched in the meantime, before they are able to produce new eggs. More than one household member is likely to be infected, so the entire household is often treated.
Medical Therapy
The medications used for the treatment of pinworm are mebendazole, pyrantel pamoate, and albendazole. All three of these drugs are to be given in 1 dose at first and then another single dose 2 weeks later. Pyrantel pamoate is available without prescription. The second dose of medication is to eliminate possible re-infection since the first dose of medication. Health practitioners and parents should weigh the health risks and benefits of these drugs for patients under 2 years of age.
Repeated infections should be treated by the same method as the first infection. In households where more than one member is infected or where repeated, symptomatic infections occur, it is recommended that all household members be treated at the same time. In institutions, mass and simultaneous treatment, repeated in 2 weeks, can be effective.
Medical Therapy and Breast Feeding
The safety of drugs used to treat pinworm have not been studied for pregnant women. If the infection is compromising the pregnancy (i.e. weight loss, sleeplessness) then treatment can be considered, but should be withheld until the 3rd trimester when the risk, if any, to the fetus is likely to be reduced.
Breastfeeding should not be withheld during mebendazole therapy. Only about 2%-10% of an oral dose is absorbed and as expected, the amounts of the drug excreted in milk are below the level of detection and appear to be clinically insignificant. Excretion in breast milk of the other drugs used to treat pinworm is not as well characterized.