Aortic regurgitation causes
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Aortic Regurgitation Microchapters |
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Diagnosis |
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Acute Aortic regurgitation |
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Chronic Aortic regurgitation |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Varun Kumar, M.B.B.S.; Lakshmi Gopalakrishnan, M.B.B.S.
Overview
Aortic insufficiency can be an acute illness or a chronic illness and the causes differ depending upon the acuity of the disease. In general, aortic insufficiency is due to abnormalities of the aortic valve itself or the aortic root. Aortic regurgitation secondary to dilation of the ascending aorta has overtaken the valvular aortic disease as the most common cause of aortic regurgitation.
Causes
Common Causes
- Worldwide the most common cause of aortic insufficiency is the rheumatic heart disease.
- In the United States, senile degenerative calcific aortic valve disease and bicuspid aortic valve disease are the most common causes.
- Aortic regurgitation secondary to dilation of the ascending aorta has overtaken valvular aortic disease as the most common cause of aortic regurgitation.
- In general, aortic insufficiency is due to abnormalities of the aortic valve itself or the aortic root.
Aortic Valve Diseases
- Rheumatic fever causes retraction of the cusps with resultant mixed aortic stenosis and aortic insufficiency with involvement of mitral valve disease.
- Infective endocarditis
- Traumatic aortic rupture following blunt chest trauma or deceleration injury.
- Congenital bicuspid aortic valve associated with increased risk of aortic dissection which then leads to aortic insufficiency.
- Dopamine agonists[1][2][3]
Aortic Root Diseases
- Hypertension
- Aortic dissection
- Marfan syndrome
- HLA-B27 positive conditions: psoriatic arthritis, ankylosing spondylitis, Reiter's syndrome
- Giant cell arteritis
- Syphilitic aortitis
Causes by Organ System
Causes in Alphabetical Order
Causes of Acute Aortic Insufficiency
- After aortic valvuloplasty[4]
- Aortic dissection: A type A dissection may disrupt the integrity of the valve leaflets causing malcoaptation of the aortic leaflets.
- Bacterial Endocarditis: The infection can erode the valve, can cause a leaflet to become flail, or a vegetation can prevent coaptation of the leaflets.
- Blunt chest trauma: Trauma can disrupt the supporting apparatus of the aortic valve.
- Myxomatous aortic valve: The valvular structure can degenerate
- Prosthetic valve dysfunction
- Rheumatic Fever
Causes of Chronic Aortic Insufficiency
- Ankylosing Spondylitis: Ankylosing spondylitis can be associated with inflammation of the aorta (aortitis).[13] The inflammatory process can also involve the septum and cause conduction disease.
- Aortic Dissection: A type A dissection may disrupt the integrity of the valve leaflets causing malcoaptation of the aortic leaflets.
- Arteriosclerosis
- Bechterew's Disease: Ankylosing spondylitis can be associated with inflammation of the aorta (aortitis).[14] The inflammatory process can also involve the septum and cause conduction disease.
- Behcet disease: Rarely, in 5% of Behcet's cases there is an aortitis that involves the ascending aorta and in some cases the coronary arteries.
- Bicuspid aortic valve: This is the most common congenital abnormality of the ehart. It is the most common cause of isolated aortic insufficiency requiring surgical repair. Bicuspid aortic valve is also associated with inflammation of the aorta (an aortopathy) which may lead to dilation of the aorta and or aortic dissection that can worsen the aortic insufficiency.[15]
- Cystic medial necrosis of the aorta
- Ehlers-Danlos Syndrome
- Giant cell arteritis: GCA may also be associated with an aortitis as well as coronary artery disease.[16]
- Hypertension
- Marfan Syndrome
- Myxomatous aortic valve
- Polymyalgia Rheumatica
- Pseudoxanthoma Elasticum
- Reiter's Syndrome
- Rheumatic Fever: Rheumatic fever remains a cause of AS in the Middle East, Northern Africa and Asia as well as some immigrant populations in the United States. It less prevalent in the US than it was in the 20th century. AR occurs as a result of fibrosis of the valve that is associated with thickening and retraction of the leaflets of the aortic valve. This retraction results in regurgitation in the center of the valve. At the same time, there may also be fusion of the aortic leaflets which results in concurrent aortic stenosis. It should be noted that rheumatic disease of the mitral valve is usually present in the same patient.
- Rheumatoid Arthritis: RA rarely causes symptomatic AR, but can as a result of granulomatous nodules that may form on the aortic leaflets.[17]
- Sinus of Valsalva Aneurysm
- Syphilis
- Systemic Lupus Erythematosus: There are tow mechanisms by which SLE can cause AR. SLE can cause inflammation and fibrosis of the aortic leaflets leading to their damage and retraction.[18] SLE can also be associated with the development of sterile verrucous vegetations on the valves called Libman-Sacks endocarditis.[19][20]
- Takayasu arteritis: Takayasu arteritis can involve the aorta in an aortitis, the aortic valve itself, and the coronary arteries.[21]
- Turner's Syndrome
- Ventricular Septal Defect
- Weight loss medications including fenfluramine and dexfenfluramine (a.k.a. Phen-Fen). These drugs have been associated with degeneration of the aortic valve.
- Whipple disease: Can involve the aortic valve.[22]
References
- ↑ Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (2007). "Dopamine agonists and the risk of cardiac-valve regurgitation". The New England Journal of Medicine. 356 (1): 29–38. doi:10.1056/NEJMoa062222. PMID 17202453. Retrieved 2011-03-28. Unknown parameter
|month=ignored (help) - ↑ Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL (2000). "Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications". Circulation. 102 (23): 2836–41. PMID 11104741. Retrieved 2011-03-28. Unknown parameter
|month=ignored (help) - ↑ Waller EA, Kaplan J, Heckman MG (2005). "Valvular heart disease in patients taking pergolide". Mayo Clinic Proceedings. Mayo Clinic. 80 (8): 1016–20. PMID 16092580. Retrieved 2011-03-28. Unknown parameter
|month=ignored (help) - ↑ 4.0 4.1 4.2 Isner JM (1991). "Acute catastrophic complications of balloon aortic valvuloplasty. The Mansfield Scientific Aortic Valvuloplasty Registry Investigators". Journal of the American College of Cardiology. 17 (6): 1436–44. PMID 2016464. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther. Feb 2008;6(2):235-48.
- ↑ Jeserich M, Ihling C, Holubarsch C. Aortic valve endocarditis with Whipple disease. Ann Intern Med. Jun 1 1997;126(11):920.
- ↑ Palazzi C, D' Angelo S, Lubrano E, Olivieri I. Aortic involvement in ankylosing spondylitis. Clin Exp Rheumatol. May-Jun 2008;26(3 Suppl 49):S131-4.
- ↑ Chand EM, Freant LJ, Rubin JW. Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol. Nov-Dec 1999;8(6):333-8.
- ↑ Chand EM, Freant LJ, Rubin JW. Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol. Nov-Dec 1999;8(6):333-8.
- ↑ Palazzi C, D' Angelo S, Lubrano E, Olivieri I. Aortic involvement in ankylosing spondylitis. Clin Exp Rheumatol. May-Jun 2008;26(3 Suppl 49):S131-4.
- ↑ Chand EM, Freant LJ, Rubin JW. Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol. Nov-Dec 1999;8(6):333-8.
- ↑ Jeserich M, Ihling C, Holubarsch C. Aortic valve endocarditis with Whipple disease. Ann Intern Med. Jun 1 1997;126(11):920.
- ↑ Palazzi C, D' Angelo S, Lubrano E, Olivieri I. Aortic involvement in ankylosing spondylitis. Clin Exp Rheumatol. May-Jun 2008;26(3 Suppl 49):S131-4.
- ↑ Palazzi C, D' Angelo S, Lubrano E, Olivieri I. Aortic involvement in ankylosing spondylitis. Clin Exp Rheumatol. May-Jun 2008;26(3 Suppl 49):S131-4.
- ↑ Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther. Feb 2008;6(2):235-48.
- ↑ Eberhardt RT, Dhadly M. Giant cell arteritis: diagnosis, management, and cardiovascular implications. Cardiol Rev. Mar-Apr 2007;15(2):55-61.
- ↑ Chand EM, Freant LJ, Rubin JW. Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol. Nov-Dec 1999;8(6):333-8.
- ↑ Jain D, Halushka MK. Cardiac pathology of systemic lupus erythematosus. J Clin Pathol. Jul 2009;62(7):584-92.
- ↑ Moyssakis I, Tektonidou MG, Vasilliou VA, Samarkos M, Votteas V, Moutsopoulos HM. Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution. Am J Med. Jul 2007;120(7):636-42.
- ↑ Lee JL, Naguwa SM, Cheema GS, Gershwin ME. Revisiting Libman-Sacks endocarditis: a historical review and update. Clin Rev Allergy Immunol. Jun 2009;36(2-3):126-30.
- ↑ Adachi O, Saiki Y, Akasaka J, Oda K, Iguchi A, Tabayashi K. Surgical management of aortic regurgitation associated with takayasu arteritis and other forms of aortitis. Ann Thorac Surg. Dec 2007;84(6):1950-3.
- ↑ Jeserich M, Ihling C, Holubarsch C. Aortic valve endocarditis with Whipple disease. Ann Intern Med. Jun 1 1997;126(11):920.