Autism future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Future or Investigational Therapies
Although many alternative therapies and interventions are available, few are supported by scientific studies. Lack of support for interventions: [1] Treatment approaches have little empirical support in quality-of-life contexts, and many programs focus on success measures that lack predictive validity and real-world relevance. Scientific evidence appears to matter less to service providers than program marketing, training availability, and parent requests.[2] Although most alternative treatments, such as melatonin, have only mild adverse effects,[3] a 2008 study found that autistic boys on casein-free diets have significantly thinner bones,[4] and botched chelation therapy killed a five-year-old autistic boy in 2005.[5]
Approximately twelve research studies are published each week on autism therapies. Three major barriers inhibit transfer of this information from the laboratory to the child:
- Treatment providers do not routinely turn to treatments that have been validated scientifically.
- A large minority of patients (actually parents of patients) resist therapies that have been scientifically validated.
- Even scientifically validated therapies are not universally effective.[6]
References
- ↑ *Francis K (2005). "Autism interventions: a critical update" (PDF). Dev Med Child Neurol. 47 (7): 493–9. doi:10.1017/S0012162205000952. PMID 15991872.
- Rao PA, Beidel DC, Murray MJ (2008). "Social skills interventions for children with Asperger's syndrome or high-functioning autism: a review and recommendations". J Autism Dev Disord. 38 (2): 353–61. doi:10.1007/s10803-007-0402-4. PMID 17641962.
- Schechtman MA (2007). "Scientifically unsupported therapies in the treatment of young children with autism spectrum disorders" (PDF). Pediatr Ann. 36 (8): 497–8, 500–2, 504–5. PMID 17849608.
- ↑ Stahmer AC, Collings NM, Palinkas LA (2005). "Early intervention practices for children with autism: descriptions from community providers". Focus Autism Other Dev Disabl. 20 (2): 66–79. PMC 1350798. PMID 16467905.
- ↑ Angley M, Semple S, Hewton C, Paterson F, McKinnon R (2007). "Children and autism—part 2—management with complementary medicines and dietary interventions" (PDF). Aust Fam Physician. 36 (10): 827–30. PMID 17925903.
- ↑ Hediger ML, England LJ, Molloy CA, Yu KF, Manning-Courtney P, Mills JL (2008). "Reduced bone cortical thickness in boys with autism or autism spectrum disorder". J Autism Dev Disord. 38 (5): 848–56. doi:10.1007/s10803-007-0453-6. PMID 17879151. Lay summary – NIH News (2008-01-29).
- ↑ Brown MJ, Willis T, Omalu B, Leiker R (2006). "Deaths resulting from hypocalcemia after administration of edetate disodium: 2003–2005". Pediatrics. 118 (2): e534–6. doi:10.1542/peds.2006-0858. PMID 16882789.
- ↑ Bodfish JW (2004). "Treating the core features of autism: are we there yet?". Ment Retard Dev Disabil Res Rev. 10 (4): 318–26. doi:10.1002/mrdd.20045. PMID 15666340.