Gangrene

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Gangrene
Diabetic with severe infection and loss of toes - wet gangrene in center.

Gangrene Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gangrene from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

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Treatment

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Primary Prevention

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Cost-Effectiveness of Therapy

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Case #1

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Risk calculators and risk factors for Gangrene

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]





Treatment

As early as 1028, when antibiotics had not yet been discovered, fly maggots were commonly used to treat chronic wounds or ulcers to prevent or arrest necrotic spread, as some species of maggots consume only dead flesh, leaving nearby living tissue unaffected. This practice largely died out after the introduction of antibiotics and enzyme to the range of treatments for wounds. Recently, however, maggot therapy has regained some credibility and is sometimes employed with great efficacy in cases of chronic tissue necrosis.

In modern times treatment is usually surgical debridement, and excision with amputation is necessary in many cases. Antibiotics alone are not effective because they do not penetrate ischemic muscles sufficiently.

See also

References

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