Cataract future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Future or Investigational Therapies
Although statins are known for their ability to lower lipids, they are also believed to have antioxidant qualities. It is believed that oxidative stress plays a role in the development of nuclear cataracts, which are the most common type of age-related cataract. To explore the relationship between nuclear cataracts and statin use, a group of researchers took a group of 1299 patients who were at risk of developing nuclear cataracts and gave some of them statins. Their results suggest that statin use in a general population may be associated with a lower risk of developing nuclear cataract disease. [1]
Research is scant and mixed but weakly positive for the nutrients lutein and zeaxanthin[2][3][4][5]. Bilberry extract shows promise in rat models [6][7] and in clinical studies.[8]
References
- ↑ Klein, Barbara. "Statin Use and Incident Nuclear Cataract". Journal of the American Medical Association. 295 (23): 2752–2758. Unknown parameter
|coauthors=ignored (help) - ↑ Nutrition. 2003 Jan;19(1):21 Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study
- ↑ Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3783-6. Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project
- ↑ Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2329-35. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study
- ↑ J Am Coll Nutr. 2004 Dec;23(6 Suppl):567S-587S Lutein and zeaxanthin and their potential roles in disease prevention
- ↑ Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats Adv Gerontol. 2005;16:76-9
- ↑ Yamakoshi J, et al. J Agric Food Chem. 2002 Aug 14;50(17):4983-8.
- ↑ Ann Ottalmol Clin Ocul, 1989