Elastase in blood serum
| Elastase in blood serum |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
- The presence of elastase in the blood serum is caused by serine proteinase hydrolyzing elastic occuring in the endothelial cells, macrophages, and granulocytes
| Reference Range | |
| In Plasma | 60-110 ng/ml |
| In Pleural Effusion | 480-2900 ng/ml |
Causes of decreased elastase in blood serum
Causes of increased elastase in blood serum[3][4]
Common Causes
- Acute lung injury[5]
- Ischemia-Reperfusion Injury[6]
- Neutrophilic asthma[7]
- Exercise[8][9]
- Celiac disease[10]
- Systolic hypertension[11]
- Endotoxemia[12]
- Diabetes mellitus[8]
- Carotid atherosclerotic plaque development[13]
- Oxidative stress[14]
- Essential thrombocythemia[15]
- Polycythemia vera[15]
- Extracorporeal detoxification[16]
- Esophagogastrectomy[17]
- Chronic joint disorders
- Hemodialysis
- Multiple trauma
- Sepsis
- Shock
- Shock lung in pre-eclampsia
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
References
- ↑ Stegenga, ME.; van der Crabben, SN.; Blümer, RM.; Levi, M.; Meijers, JC.; Serlie, MJ.; Tanck, MW.; Sauerwein, HP.; van der Poll, T. (2008). "Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia". Blood. 112 (1): 82–9. doi:10.1182/blood-2007-11-121723. PMID 18316629. Unknown parameter
|month=ignored (help) - ↑ de Kruif, MD.; Lemaire, LC.; Giebelen, IA.; van Zoelen, MA.; Pater, JM.; van den Pangaart, PS.; Groot, AP.; de Vos, AF.; Elliott, PJ. (2007). "Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia". J Immunol. 178 (3): 1845–51. PMID 17237435. Unknown parameter
|month=ignored (help) - ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
- ↑ Donnelly, SC.; MacGregor, I.; Zamani, A.; Gordon, MW.; Robertson, CE.; Steedman, DJ.; Little, K.; Haslett, C. (1995). "Plasma elastase levels and the development of the adult respiratory distress syndrome". Am J Respir Crit Care Med. 151 (5): 1428–33. doi:10.1164/ajrccm.151.5.7735596. PMID 7735596. Unknown parameter
|month=ignored (help) - ↑ Hughes, SF.; Cotter, MJ.; Evans, SA.; Jones, KP.; Adams, RA. (2006). "Role of leucocytes in damage to the vascular endothelium during ischaemia-reperfusion injury". Br J Biomed Sci. 63 (4): 166–70. PMID 17201205.
- ↑ Baines, KJ.; Simpson, JL.; Wood, LG.; Scott, RJ.; Gibson, PG. (2011). "Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma". Thorax. 66 (11): 942–7. doi:10.1136/thx.2010.157719. PMID 21785157. Unknown parameter
|month=ignored (help) - ↑ 8.0 8.1 Hu, H.; Johansson, BL.; Hjemdahl, P.; Li, N. (2004). "Exercise-induced platelet and leucocyte activation is not enhanced in well-controlled Type 1 diabetes, despite increased activity at rest". Diabetologia. 47 (5): 853–9. doi:10.1007/s00125-004-1378-7. PMID 15095037. Unknown parameter
|month=ignored (help) - ↑ Li, N.; He, S.; Blombäck, M.; Hjemdahl, P. (2007). "Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin". Arterioscler Thromb Vasc Biol. 27 (2): 407–13. doi:10.1161/01.ATV.0000253906.19648.ac. PMID 17138937. Unknown parameter
|month=ignored (help) - ↑ Carroccio, A.; Di Prima, L.; Scalici, C.; Soresi, M.; Cefalù, AB.; Noto, D.; Averna, MR.; Montalto, G.; Iacono, G. (2006). "Unexplained elevated serum pancreatic enzymes: a reason to suspect celiac disease". Clin Gastroenterol Hepatol. 4 (4): 455–9. doi:10.1016/j.cgh.2005.12.027. PMID 16616350. Unknown parameter
|month=ignored (help) - ↑ Yasmin, CM.; McEniery, S.; Wallace, Z.; Dakham, P.; Pulsalkar, P.; Pusalkar, K.; Maki-Petaja, MJ.; Ashby, JR.; Cockcroft, IB. (2005). "Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness". Arterioscler Thromb Vasc Biol. 25 (2): 372. doi:10.1161/01.ATV.0000151373.33830.41. PMID 15556929. Unknown parameter
|month=ignored (help) - ↑ O'Brien, JM.; Abraham, E. (2004). "Human models of endotoxemia and recombinant human activated protein C.". Crit Care Med. 32 (5 Suppl): S202–8. PMID 15118518. Unknown parameter
|month=ignored (help) - ↑ Zureik, M.; Robert, L.; Courbon, D.; Touboul, PJ.; Bizbiz, L.; Ducimetière, P. (2002). "Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques: the Etude sur le Vieillissement Artériel (EVA) study". Circulation. 105 (22): 2638–45. PMID 12045170. Unknown parameter
|month=ignored (help) - ↑ Clermont, G.; Lecour, S.; Cabanne, JF.; Motte, G.; Guilland, JC.; Chevet, D.; Rochette, L. (2001). "Vitamin E-coated dialyzer reduces oxidative stress in hemodialysis patients". Free Radic Biol Med. 31 (2): 233–41. PMID 11440835. Unknown parameter
|month=ignored (help) - ↑ 15.0 15.1 Falanga, A.; Marchetti, M.; Evangelista, V.; Vignoli, A.; Licini, M.; Balicco, M.; Manarini, S.; Finazzi, G.; Cerletti, C. (2000). "Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera". Blood. 96 (13): 4261–6. PMID 11110700. Unknown parameter
|month=ignored (help) - ↑ Kramer, L.; Gendo, A.; Madl, C.; Ferrara, I.; Funk, G.; Schenk, P.; Sunder-Plassmann, G.; Hörl, WH. (2000). "Biocompatibility of a cuprophane charcoal-based detoxification device in cirrhotic patients with hepatic encephalopathy". Am J Kidney Dis. 36 (6): 1193–200. doi:10.1053/ajkd.2000.19834. PMID 11096044. Unknown parameter
|month=ignored (help) - ↑ Reid, PT.; Donnelly, SC.; MacGregor, IR.; Grant, IS.; Cameron, E.; Walker, W.; Merrick, MV.; Haslett, C. (2000). "Pulmonary endothelial permeability and circulating neutrophil-endothelial markers in patients undergoing esophagogastrectomy". Crit Care Med. 28 (9): 3161–5. PMID 11008975. Unknown parameter
|month=ignored (help)