Faget's sign
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Template:GCC
Overview
In medicine, the Faget sign is the unusual constellation of fever and bradycardia (a slow pulse). It is often seen in yellow fever.
Fever is usually accompanied by tachycardia (a fast pulse). Physiologically, for each degree increase in temperature in degrees Fahrenheit, there is a commensurate increase in the heart rate of 10 beats/min (Liebermeister's rule), except in situations where there is a relative bradycardia in a patient with a fever (Faget's Sign).
Causes[1][2]
Common Causes
- Brucellosis
- Chlamydia[3]
- Colorado tick fever virus
- Coxiella burnetii
- Dengue Fever[4]
- Drug fever (eg, Beta-blockers)
- Legionella[3][5]
- Leptospirosis
- Leishmaniasis
- Mycoplasma[3]
- Psittacosis
- Tularemia
- Typhoid fever
- Yellow Fever
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | Anaphylaxis, Orientia tsutsugamushi |
| Drug Side Effect | Beta blocker, Drug fever |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Cyclic neutropenia |
| Hematologic | Babesiosis, Cyclic neutropenia, Lymphoma, Malaria |
| Iatrogenic | No underlying causes |
| Infectious Disease | Atypical pneumonia, Babesiosis, Brucellosis, Campylobacter fetus, Chagas disease, Chlamydia, Chlamydophila psittaci, Colorado tick fever virus, Coxiella burnetii, Cytomegalovirus mononucleosis, Dengue fever, Ehrlichia canis, Enteric fever, Francisella tularensis, Group A streptococcus, Guanarito virus, Junin virus, Legionnaires' disease, Leishmaniasis, Leptospirosis, Listeria monocytogenes, Machupo virus, Malaria, Mycoplasma, Orientia tsutsugamushi, Plasmodium vivax , Q fever, Rickettsia typhi, Rickettsiosis, Rocky mountain spotted fever, Salmonella enterica, Typhoid fever, Viral hemorrhagic fever, Yellow fever |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | Central nevous system lesion |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Lymphoma |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Atypical pneumonia |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | Anaphylaxis |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | Factitious fever |
Causes in Alphabetical Order
Reference
- ↑ Cunha, BA. (2000). "The diagnostic significance of relative bradycardia in infectious disease". Clin Microbiol Infect. 6 (12): 633–4. PMID 11284920. Unknown parameter
|month=ignored (help) - ↑ Wittesjö, B.; Björnham, A.; Eitrem, R. (1999). "Relative bradycardia in infectious diseases". J Infect. 39 (3): 246–7. PMID 10714809. Unknown parameter
|month=ignored (help) - ↑ 3.0 3.1 3.2 Johnson, DH.; Cunha, BA. (1993). "Atypical pneumonias. Clinical and extrapulmonary features of Chlamydia, Mycoplasma, and Legionella infections". Postgrad Med. 93 (7): 69–72, 75–6, 79–82. PMID 8493198. Unknown parameter
|month=ignored (help) - ↑ Senanayake, S. (2006). "Dengue fever and dengue haemorrhagic fever--a diagnostic challenge". Aust Fam Physician. 35 (8): 609–12. PMID 16894436. Unknown parameter
|month=ignored (help) - ↑ Erdogan, H.; Erdogan, A.; Lakamdayali, H.; Yilmaz, A.; Arslan, H. (2010). "Travel-associated Legionnaires disease: clinical features of 17 cases and a review of the literature". Diagn Microbiol Infect Dis. 68 (3): 297–303. doi:10.1016/j.diagmicrobio.2010.07.023. PMID 20955914. Unknown parameter
|month=ignored (help)
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