High density lipoprotein future or investigational therapies
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High Density Lipoprotein Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
Overview
There are promising future therapies that include CETP inhibitors, which are currently in the experimental phase. A combination therapy with statins and ACE inhibitors is also a safe option in patients with HDL levels who also share features with dysmetabolic syndrome. However, the preventive effects of these two drugs tend to be cumulative.[1]
The Need
HDL Infusion/Mimetics
Clinical Significance
Medications
ApoA-1 Milano
CSL-112
CER-001
APP018
Potential Therapeutic Considerations
Cholesterol Ester Transfer Protein (CETP) Inhibition
Torcetrapib
Dalcetrapib
Anacetrapib
Evacetrapib
Other Therapies
De-lipidated HDL
Endocannabinoid Receptor Blockers
JTT-705
CETi-1 Vaccine
RVX-208
References
- ↑ Liem AH, Jukema JW, van Veldhuisen DJ (2003). "Secondary prevention in coronary heart disease patients with low HDL: which options do we have?". International Journal of Cardiology. 90 (1): 15–21. PMID 12821213. Unknown parameter
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