WBR0477
| Author | [[PageAuthor::Rim Halaby, M.D. [1], Alison Leibowitz [2] (Reviewed by Alison Leibowitz)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Behavioral Science/Psychiatry, MainCategory::Pharmacology |
| Sub Category | SubCategory::Hematology |
| Prompt | [[Prompt::A 19-year-old male is admitted to the hospital for auditory hallucinations and delusions, with a duration of over 1 year. The patient has schizophrenia and is refractory to antipsychotic treatment. The physician decides to start the patient on clozapine despite associated risks. Which of the following lab tests should be routinely performed to monitor for clozapine adverse reaction?]] |
| Answer A | AnswerA::Liver transaminases |
| Answer A Explanation | [[AnswerAExp::Liver transaminase testing is not routinely performed upon clozapine administration.]] |
| Answer B | AnswerB::Creatinine |
| Answer B Explanation | [[AnswerBExp::Creatinine testing is not routinely performed upon clozapine administration.]] |
| Answer C | AnswerC::Complete blood count (CBC) |
| Answer C Explanation | [[AnswerCExp::Due to the risk of agranulocytosis, a CBC must be routinely performed in patients administered clozapine.]] |
| Answer D | AnswerD::Electrolyte panel |
| Answer D Explanation | [[AnswerDExp::Electrolyte panel testing is not routinely performed upon clozapine administration.]] |
| Answer E | AnswerE::Fasting blood glucose |
| Answer E Explanation | [[AnswerEExp::Fasting blood glucose testing is not routinely performed upon clozapine administration.]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::Clozapine, a second generation antipsychotic medication, is highly effective in the treatment of symptoms characteristic of schizophrenia. Clozapine is reserved for refractory cases of schizophrenia, due to its association with agranulocytosis in approximately 1% of patients. Periodic complete blood count (CBC) must be performed in patients administered clozapine, to monitor for any signs of agranulocytosis. Educational Objective: Clozapine, a second generation antipsychotic medication, is highly effective in the treatment of symptoms characteristic of schizophrenia. Clozapine is reserved for refractory cases of schizophrenia, due to its association with agranulocytosis in approximately 1% of patients. |
| Approved | Approved::Yes |
| Keyword | WBRKeyword::schizophrenia, WBRKeyword::clozapine, WBRKeyword::antipsychotics, WBRKeyword::second generation antipsychotics, WBRKeyword::agranulocytosis, WBRKeyword::adverse drug reaction, WBRKeyword::side effect, WBRKeyword::CBC, WBRKeyword::complete blood count, WBRKeyword::monitoring, WBRKeyword::mental health, WBRKeyword::neurological |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |