WBR0509
| Author | [[PageAuthor::Gonzalo A. Romero, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pharmacology |
| Sub Category | SubCategory::Reproductive |
| Prompt | [[Prompt::A 61-year-old male comes to the clinic due to hair loss. He has a progressive history of baldness. He has tried many topical ointments and different products seen on TV, which have not been very helpful. He would like to look younger and to prevent losing further hair. The family doctor considers using Finasteride to treat his condition. Which of the following is true about the mechanism of action of this drug?]] |
| Answer A | AnswerA::It is a non-steroidal competitive inhibitor of androgens at the testosterone receptor |
| Answer A Explanation | [[AnswerAExp::Incorrect. It is incorrect because]] |
| Answer B | AnswerB::Inhibits the synthesis of steroid |
| Answer B Explanation | [[AnswerBExp::Incorrect. It is incorrect because]] |
| Answer C | AnswerC::Inhibits the conversion of testosterone to DHT |
| Answer C Explanation | [[AnswerCExp::Correct. It is incorrect because]] |
| Answer D | AnswerD::Inhibits steroid binding |
| Answer D Explanation | [[AnswerDExp::Incorrect. This patient is presenting with:]] |
| Answer E | AnswerE::Binds to estrogen receptors |
| Answer E Explanation | [[AnswerEExp::Incorrect. It is incorrect because]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::Finasteride is used for BPH (benigh prostatic hyperplasia) and to treat male-pattern baldness,because it promotes hair growth. It is an 5 alfa-reductase inhibitor (normally converts testosterone to DHT), decreasing the conversion of testosterone to DHT (dihydrotestosterone). Educational Objective: |
| Approved | Approved::No |
| Keyword | WBRKeyword::Testosterone agonist, WBRKeyword::testosterone antagonist |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |