Ticarcillin disodium

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Template:Ticarcillin disodium Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Ticarcillin is a carboxypenicillin. It is almost invariably sold and used in combination with clavulanate as Ticarcillin/clavulanic acid-TIMENTIN. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram-negative bacteria, particularly Pseudomonas aeruginosa. It is also one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections.

Category

beta-lactam antibiotics

US Brand Names

TIMENTIN®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied

Mechanism of Action

Ticarcillin disrupts bacterial cell wall development by inhibiting peptidoglycan synthesis and/or by interacting with penicillin‑binding proteins.[1]

References

  1. "TIMENTIN (TICARCILLIN DISODIUM AND CLAVULANATE POTASSIUM) INJECTION, POWDER, FOR SOLUTION TIMENTIN (TICARCILLIN DISODIUM AND CLAVULANATE POTASSIUM) INJECTION, SOLUTION [GLAXOSMITHKLINE LLC]". Text " accessdate" ignored (help)