Indinavir
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
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Overview
Indinavir is an antiretroviral agent and protease inhibitor that is FDA approved for the treatment of HIV infection in combination with other antiretroviral agents. Common adverse reactions include abdominal pain, heartburn, loss of appetite, nausea, taste sense altered, vomiting, neutrophil count abnormal, hyperbilirubinemia and headache.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Indinavir FDA-Labeled Indications and Dosage (Adult) in the drug label.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Indinavir in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Indinavir in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Indinavir FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Indinavir in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Indinavir in pediatric patients.
Contraindications
There is limited information regarding Indinavir Contraindications in the drug label.
Warnings
There is limited information regarding Indinavir Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Indinavir Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Indinavir Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Indinavir Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Indinavir in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Indinavir in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Indinavir during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Indinavir in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Indinavir in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Indinavir in geriatric settings.
Gender
There is no FDA guidance on the use of Indinavir with respect to specific gender populations.
Race
There is no FDA guidance on the use of Indinavir with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Indinavir in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Indinavir in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Indinavir in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Indinavir in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Indinavir Administration in the drug label.
Monitoring
There is limited information regarding Indinavir Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Indinavir and IV administrations.
Overdosage
There is limited information regarding Indinavir overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Indinavir Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Indinavir Mechanism of Action in the drug label.
Structure
There is limited information regarding Indinavir Structure in the drug label.
Pharmacodynamics
There is limited information regarding Indinavir Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Indinavir Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Indinavir Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Indinavir Clinical Studies in the drug label.
How Supplied
There is limited information regarding Indinavir How Supplied in the drug label.
Storage
There is limited information regarding Indinavir Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Indinavir Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Indinavir interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Indinavir Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Indinavir Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [4]
Overview
Indinavir (IDV; trade name Crixivan, manufactured by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.
Category
US Brand Names
CRIXIVAN®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Dosage and Administration | How Supplied
Mechanism of Action
HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles.[1]
References
- ↑ "CRIXIVAN (INDINAVIR SULFATE) CAPSULE [MERCK SHARP & DOHME CORP.]". Text " accessdate" ignored (help)