Isosorbide mononitrate drug interactions
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
The concomitant administration of agents with hypotensive effects and psychotherapeutic agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics), narcotic analgesics, alcohol, or muscle relaxants may additively increase hypotensive and/or central nervous system depressant effects
Major Interactions
Moderate Interactions
- 40 Winks
- Abilify
- Abilify Discmelt
- Accupril
- Aceon
- Actiq
- Activase
- Adapin
- Adgan
- Aler-Dryl
- Aler-Tab
- Alfenta
- alfentanil
- All Day Allergy
- Allergia-C
- Allermax
- alprazolam
- alprazolam extended release
- Altace
- Altaryl
- alteplase
- Ambien
- Ambien CR
- amitriptyline
- amoxapine
- Anafranil
- Anergan 50
- Antiflex
- Antinaus 50
- APO-Go
- APO-Go Pen
- Apokyn
- apomorphine
- Aquachloral Supprettes
- aripiprazole
- Asendin
- Astramorph PF
- Atarax
- Ativan
- Aventyl HCl
- Avinza
- baclofen
- Banaril
- Banflex
- Banophen
- Beldin
- Belix
- Ben-Tann
- Benadryl
- Benadryl Allergy
- Benadryl Child Dye Free
- Benadryl Childrens Allergy Fastmelt
- Benadryl DF
- Benadryl Dye Free Allergy
- Benadryl Ultratab
- Benahist-10
- Benahist-50
- Benoject-50
- bromocriptine
- Budeprion SR
- Budeprion XL
- Buprenex
- Buprenorphine
- bupropion
- bupropion 24 hour extended release
- bupropion extended release
- Busodium
- BuSpar
- BuSpar Dividose
- buspirone
- butabarbital
- Butisol Sodium
- Bydramine
- cabergoline
- Calm-Aid
- Capoten
- captopril
- Carbacot
- Cathflo Activase
- Celexa
- cetirizine
- chloral hydrate
- chlordiazepoxide
- chlorpromazine
- chlorpromazine extended release
- citalopram
- clomipramine
- clonazepam
- Clopine
- clorazepate
- clorazepate extended release
- clozapine
- Clozapine Synthon
- Clozaril
- codeine
- codeine phosphate
- codeine sulfate
- Compazine
- Compazine Spansule
- Compoz Nighttime Sleep Aid
- Compro
- D.H.E. 45
- Dalmane
- Darvon
- Darvon-N
- Dazidox
- Demerol HCl
- Denzapine
- Desyrel
- Desyrel Dividose
- Diastat
- Diastat AcuDial
- Diastat Pediatric
- diazepam
- dihydrocodeine
- dihydroergotamine
- Dilaudid
- Dilaudid-5
- Dilaudid-HP
- Diphedryl
- Diphen
- Diphen AF
- Diphen Cough
- Diphenadryl
- Diphendryl
- Diphenhist
- diphenhydramine
- diphenhydramine citrate
- diphenhydramine tannate
- Diphenmax
- Diphenydramine Quick Melt
- Diphenyl
- Diphenylin
- Diskets
- Dizac
- Dolophine
- Doloral
- Doloral Sirop
- Doral
- Dostinex
- doxepin
- doxepin topical
- DPH
- Duragesic
- Duragesic-100
- Duragesic-12
- Duragesic-25
- Duragesic-50
- Duragesic-75
- Duramorph PF
- Dytan
- Dytuss
- Effexor
- Effexor XR
- Elavil
- enalapril
- enalaprilat
- Endep
- Endocodone
- Equanil
- Ergomar
- ergonovine
- ergotamine
- Ergotrate Maleate
- escitalopram
- ETH-Oxydose
- FazaClo
- fentanyl
- Fentora
- Flexoject
- Flexon
- fluoxetine
- fluoxetine extended release
- fluphenazine
- fluphenazine decanoate
- fluphenazine enanthate
- fluphenazine hydrochloride
- flurazepam
- fluvoxamine
- fluvoxamine extended release
- fosinopril
- Genahist
- Geodon
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- Hydramine
- Hydramine Compound
- Hydramine Cough Syrup
- Hydromorph Contin
- hydromorphone
- hydromorphone extended release
- Hydrostat IR
- hydroxyzine
- hydroxyzine hydrochloride
- hydroxyzine pamoate
- Hyrexin
- Hyzine
- iloprost
- imipramine
- imipramine pamoate
- Infumorph
- Invega
- Ionsys
- Kadian
- Klonopin
- Klonopin Wafer
- levocetirizine
- Levrix
- Lexapro
- Librium
- Lioresal
- Lioresal Intrathecal
- lisinopril
- lorazepam
- loxapine
- Loxitane
- Loxitane C
- Loxitane IM
- Ludiomil
- Luminal
- Luvox
- Luvox CR
- M-Eslon
- M-Oxy
- M. O. S.
- maprotiline
- maraviroc
- Mavik
- MB-TAB
- Mellaril
- Mellaril-S
- meperidine
- meprobamate
- methadone
- Methadose
- methdilazine
- Methergine
- methocarbamol
- methylergonovine
- methysergide maleate
- midazolam
- Migranal
- Miltown
- minoxidil topical
- Mio-Rel
- mirtazapine
- Mitran
- moexipril
- Monopril
- morphine
- morphine 24 hour extended release
- morphine extended release
- Morphine IR
- Morphine LP Epidural
- morphine preservative-free
- Morphine Rapi-Ject
- Morphitec
- MS
- MS Contin
- MS/S
- MSIR
- Myolin
- nalbuphine
- Natrecor
- nefazodone
- Nervine
- nesiritide
- Nightime Sleepaid
- Niravam
- Norflex
- Norflex Injectable
- nortriptyline
- Nu-Med
- Nubain
- Nytol Caplet
- olanzapine
- OMS
- opium
- Opium Deodorized
- Oramorph SR
- Orfro
- Ormazine
- orphenadrine
- orphenadrine extended release
- Orphenate
- oxazepam
- oxycodone
- oxycodone extended release
- OxyContin
- Oxyfast
- OxyIR
- paliperidone
- Palladone
- Palladone SR
- Pamelor
- Paral
- paraldehyde
- Pardryl
- Paregoric
- Parlodel
- paroxetine
- paroxetine extended release
- paroxetine mesylate
- Paxil
- Paxil CR
- Pentazine
- pentazocine
- Percolone
- perindopril
- Permitil
- perphenazine
- Pexeva
- Phenadoz
- Phenazine 50
- Phenergan
- Phenergan Fortis
- phenobarbital
- Phenoject-50
- PP-Cap
- Prinivil
- Pro-Med
- prochlorperazine
- prochlorperazine extended release
- Procot
- Prolixin
- Prolixin Decanoate
- Prolixin Enanthate
- Promacot
- promazine
- promethazine
- Promethegan
- propoxyphene
- propoxyphene hydrochloride
- propoxyphene napsylate
- Prorex
- Prozac
- Prozac Weekly
- Prudoxin
- Q-Dryl
- Q-Dryl A/F
- quazepam
- Quenalin
- quetiapine
- quetiapine extended release
- quinapril
- ramipril
- Rapiflux
- Remeron
- Remeron SolTab
- Rescudose
- Restoril
- Rezine
- Risperdal
- Risperdal Consta
- Risperdal M-Tab
- risperidone
- RMS
- Robaxin
- Robaxin-750
- Rogaine
- Rogaine Extra Strength
- Ronoxidil
- Roxanol
- Roxanol 100
- Roxanol-T
- Roxicodone
- Roxicodone Intensol
- Sansert
- Sarafem
- Scot-Tussin Allergy Relief Formula
- secobarbital
- Seconal Sodium
- Selzentry
- Serax
- Seroquel
- Seroquel XR
- sertraline
- Serzone
- Siladryl
- Siladryl DAS
- Siladyl SA
- Silphen Cough
- Simply Sleep
- Sinequan
- Skelex
- Sleep Tab II
- Sleep Tabs
- Sleep-ettes
- Sleep-Eze-3
- Sleepinal
- Solfoton
- Sominex
- Sominex Maximum Strength Caplet
- Somnicaps
- Somnote
- Sonata
- Sparine
- Statex
- Stelazine
- Sublimaze
- Subutex
- Surmontil
- Tacaryl
- Talwin Lactate
- temazepam
- Theraflu Thin Strips Multi Symptom
- thioridazine
- Thorazine
- tissue plasminogen activator
- Tofranil
- Tofranil-PM
- Total Allergy
- TPA
- trandolapril
- Tranxene SD
- Tranxene T-Tab
- trazodone
- Triaminic Thin Strips Cough & Runny Nose
- trifluoperazine
- Trilafon
- trimipramine
- Trux-adryl
- Tusstat
- Twilite
- Uni-Tann
- Unisom Sleepgels Maximum Strength
- Univasc
- Uprima
- V-Gan-25
- V-Gan-50
- Valium
- Valrelease
- Valu-Dryl
- Vanatrip
- Vasotec
- venlafaxine
- venlafaxine extended release
- Ventavis
- Versed
- verteporfin
- Vistacon
- Vistacot
- Vistaject-50
- Vistaril
- Vistaril IM
- Vistazine
- Vistazine 50
- Visudyne
- Wellbutrin
- Wellbutrin SR
- Wellbutrin XL
- Xanax
- Xanax XR
- Xyzal
- Xyzall
- zaleplon
- Zaponex
- Zestril
- Zetran
- ziprasidone
- Zoloft
- zolpidem
- zolpidem extended release
- Zonalon
- Zyban
- Zyban Advantage Pack
- Zyprexa
- Zyprexa Zydis
- Zyrtec
- Zyrtec Hives
Minor Interactions
- apraclonidine ophthalmic
- Atapryl
- Azilect
- Carbex
- Eldepryl
- Emsam
- furazolidone
- Furoxone
- Iopidine
- isocarboxazid
- Jumex
- linezolid
- Marplan
- Matulane
- Nardil
- omeprazole
- Parnate
- phenelzine
- Prilosec
- Prilosec OTC
- procarbazine
- rasagiline
- selegiline
- Selgene
- tranylcypromine
- Zegerid (Original Formulation)
- Zelapar
- Zyvox
LABORATORY TEST INTERACTIONS
Nitrates and nitrites may interfere with the Zlatkis-Zak color reaction, causing falsely low readings in serum cholesterol determinations.[1]
References
- ↑ "ISOSORBIDE MONONITRATE TABLET [ZYDUS PHARMACEUTICALS (USA) INC.]". Retrieved 30 January 2014.
Adapted from the FDA Package Insert.