Hepatotoxicity epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology
Drug-related hepatotoxicity is generally considered as an uncommon complication for many drugs, with an incidence between 1 in 10,000 and 1 in 100,000.[1] The incidence of hepatotoxicity is hard to determine, partly because of difficulties in detection as well as the lack of unified criteria for diagnosis.
One study from France reported a crude annual incidence of 13.9 ± 2.4 per 100,000 inhabitants, which is 16 times greater than the number noted by spontaneous reporting to French regulatory authorities. The true incidence of hepatic adverse events in the general population remains unknown and is often underestimated.[1]